Cell Migration Laboratory
Docent in Cell Biology
Senior Scientist (Specialforskare) at Åbo Akademi University
Email: guillaume.jacquemet [at] abo.fi
Turku Bioscience P.O. Box 123, BioCity
(Street addr. Tykistökatu 6 B)
FIN-20521 Turku, Finland
Phone +358 505012574
Description of the Research
There is a pressing need to develop strategies that block cancer cell dissemination and metastasis, the primary cause of death in patients with solid tumours. My lab is interested in elucidating the mechanisms by which cancer cells spread through the body. In particular we aim to gain fundamental insight into how filopodia, specialized protrusions used by cells to explore their immediate surroundings (composed of the extracellular matrix as well as other cells), drive cancer progression and, ultimately, to identify new lines of therapeutic intervention.
In tumours of epithelial origin, cancer cell dissemination begins following local cell invasion through a basement membrane into the surrounding stroma. We discovered that i) cancer cells extend filopodia during local invasion, ii) filopodia formation correlates with disease progression, iii) filopodia are very abundant both at cell-cell and cell-ECM interfaces as cancer cells invade collectively and iv) cancer cells exploit filopodia at later stages of disease when interacting with the vasculature in vivo.
Software and tools
Visit our Github page.