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UID:1010@bioscience.fi
DTSTART;TZID=Europe/Helsinki:20240318T000000
DTEND;TZID=Europe/Helsinki:20240318T000000
DTSTAMP:20250304T083756Z
URL:https://bioscience.fi/events/114627/
SUMMARY:Dissertation Defence: Mukund Sharma
DESCRIPTION:MSc Mukund Sharma defended his dissertation titled "Convergence
  of RAS and PP2A activities on chromatin repressor complexes" on Friday\, 
 March 22\, 2024.\n\nDownload the dissertation\n\nAbstract of the doctoral 
 dissertation:\n\nHuman cells contain specialized receptors on their surfac
 e that communicate with the extracellular factors and pass on the appropri
 ate messages to the interior of the cells. These messages include the timi
 ng for cell division and growth.\n\nRAS proteins receive these messages an
 d further pass them on to other proteins finally reaching the nucleus. Spe
 cialized proteins in the nucleus (epigenetic proteins) can then unlock the
  DNA resulting in the tranion of appropriate genes. This results in cell g
 rowth and division. Once the job is done another protein (PP2A) signals to
  lock the DNA stopping further growth. This process of sending messages to
  the cell interior and its proper implementation is tightly controlled and
  maintains normal growth and division.\n\nA major cause of cancer is hyper
 activation of the growth signal carrier protein (RAS) and inactivation of 
 the signal terminator protein (PP2A). This keeps the DNA in an unlocked st
 ate resulting in continuous cell division. It is however not known how RAS
  and PP2A communicate with the epigenetic proteins that lock or unlock the
  DNA.\n\nIn my Ph.D. thesis\, I have tried to understand how RAS and PP2A 
 communicate with the epigenetic proteins. Using specialized tools\, I have
  documented the interaction between RAS\, PP2A\, and epigenetic proteins. 
 In this study\, I found out that both RAS and PP2A can modify some of thes
 e proteins resulting in either locking or unlocking of the DNA. This tug-o
 f-war between RAS and PP2A has a major implication for cancer therapy. I i
 dentified that by promoting the PP2A-mediated epigenetic communication whi
 le inhibiting RAS-mediated\, we can restore cellular balance. My study des
 cribes a novel cellular communication between a tumor promoter and a tumor
  suppressor and how it can be utilized in preventing cancer.
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