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UID:186915@bioscience.fi
DTSTART;TZID=Europe/Helsinki:19700101T000000
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DTSTAMP:20260427T045956Z
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SUMMARY:Breaking Boundaries: From the Cell’s Edge to the Heart of Gene Ex
 pression
DESCRIPTION:Proteins are typically located in particular compartments withi
 n the cell\, where they perform specific functions. However\, proteins can
  also be found in unexpected cellular locations\, suggesting that they mig
 ht play novel roles yet to be discovered.\nA team of researchers at Åbo A
 kademi University\, led by Professor Lea Sistonen (Professor of Cell and M
 olecular Biology) and Docent Eva Henriksson (University Lecturer in Cell B
 iology)\, made a surprising discovery. They found that Talin-1\, a protein
  primarily known for its role in cell adhesion at the periphery of the cel
 l\, can also be located in the cell nucleus\, where the genetic material r
 esides. Remarkably\, nuclear Talin-1 was shown to influence the expression
  of genes that regulate cell-to-cell connections.\n\n“Our results were s
 urprising and required extensive verification\, as Talin-1 has been studie
 d for decades outside the nucleus\, thereby challenging the established vi
 ew of how Talin-1 functions”\, explains Dr. Alejandro Da Silva\, who is 
 the first author of the recently published article entitled “Nuclear tal
 in-1 provides a bridge between cell adhesion and gene expression”.\n\nIn
  the periphery of the cell\, Talin-1 senses mechanical forces\, stabilizes
  the adhesion of cells to their surroundings and facilitates cell movement
 s in the body. Therefore\, the surprising finding of nuclear Talin-1 raise
 s numerous questions for future investigations. For example\, how Talin-1 
 travels to the nucleus and whether sensing mechanical forces is required f
 or its capacity to control gene expression. This discovery in basic Cell B
 iology has important medical implications\, because mutations in Talin-1 h
 ave been linked to several diseases\, such as cancer\, cardiomyopathies\, 
 and hematologic disorders. Consequently\, Talin-1 has already been suggest
 ed as an attractive drug target. Advancing our understanding of Talin-1’
 s cellular localization and function is therefore a critical step towards 
 exploring its therapeutic potential.\n\nThis research was conducted within
  the CellMech Center of Excellence in Mechanostasis (2019–2023) at Åbo 
 Akademi University. The CellMech project aimed to investigate how mechanic
 al signals affect the functioning of cells and tissues. The study was fina
 ncially supported by the Finnish Cultural Foundation and the Ella ja Georg
  Ehrnrooth Foundation. The results were published in iScience\, an open ac
 cess journal which belongs to Cell Press and can be found here.\n\nFor fur
 ther information please contact:\n\nLea Sistonen\, Professor of Cell and M
 olecular Biology\nE-mail: lea.sistonen@abo.fi\nTelephone: 02-2153311\, 050
 -4013513\n\nEva Henriksson\nE-mail: eva.henriksson@abo.fi\n\nAlejandro Da 
 Silva\nE-mail: adasilva@abo.fi\n\nLink to original press release &gt\;&gt\
 ;
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