BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.2.3.1//EN
TZID:Europe/Helsinki
X-WR-TIMEZONE:Europe/Helsinki
BEGIN:VEVENT
UID:1038@bioscience.fi
DTSTART;TZID=Europe/Helsinki;VALUE=DATE:20231024
DTEND;TZID=Europe/Helsinki;VALUE=DATE:20231025
DTSTAMP:20250304T083757Z
URL:https://bioscience.fi/events/dissertation-defence-fm-emmi-lokka/
SUMMARY:Emmi Lokka from Rantakari group defended her dissertation in Medica
 l Microbiology and Immunology
DESCRIPTION:FM Emmi Lokka defended the dissertation in Medical Microbiology
  and Immunology entitled “Foetal monocytes and their journey from liver 
 to periphery: PLVAP marks the exit” at the University of Turku on 24 Oct
 ober 2023 at 12.00 (University of Turku\, Dentalia\, Arje Scheinin lecture
  hall\, Lemminkäisenkatu 2\, Turku).\n\nOpponent: Professor Steffen Jung 
 (Weizmann Institute of Science\, Israel)\nCustos: Docent Pia Rantakari (Un
 iversity of Turku)\n\nDoctoral Dissertation at UTUPub: https://urn.fi/URN:
 ISBN:978-951-29-9480-9\n\nABSTRACT\n\nEndothelium is the barrier between t
 he blood and tissue stroma. Cells and macromolecules are selectively allow
 ed to traffic through the endothelium to maintain homeostasis. Besides the
  paracellular transport route at the cell-cell junctions\, transcellular p
 athways also exist. Fenestrae\, transendothelial channels\, and caveolae a
 re specific structures of endothelial cells. They may be covered by a filt
 ering unit called diaphragm\, which is a proteinaceous structure that cons
 ists only of plasmalemma vesicle associated protein (PLVAP). PLVAP is know
 n to participate in molecular sieving and cellular transmigration through 
 the endothelium. Nevertheless\, the role of PLVAP in the transendothelial 
 cell migration has not been described during the foetal era.\nThe aims of 
 this thesis were to study if PLVAP is functional in leukocyte trafficking 
 in the foetal liver and to examine the dynamics of PLVAP expression in the
  liver sinusoidal endothelium. We found that PLVAP was needed for the effi
 cient exit of foetal macrophage precursors from the liver to the bloodstre
 am. Moreover\, we discovered that the resident macrophage populations in a
 dult mice were diminished under PLVAP deficiency. Surprisingly\, we also o
 bserved nondiaphragmal PLVAP expression in the sinusoids of postnatal live
 r that persisted until adulthood. Finally\, we aimed to study the resident
  macrophage ontogeny in depth in testis\, which is known to accommodate a 
 substantial macrophage population. Using the PLVAP-deficient mice and othe
 r models we revealed that testicular macrophages are mostly derived from f
 oetal origins and that circulating monocytes in the adult mice have a negl
 igible contribution to them. Furthermore\, we showed that the resident mac
 rophages in foetal testis are crucial for the normal spermatogenesis in mi
 ce.\n\nThese results are encouraging for further investigation of PLVAP fu
 nctionalities in the context of general transendothelial leukocyte migrati
 on\, but also for studying the functions of PLVAP outside diaphragms. Equa
 lly intriguing will be to further examine the functions of macrophages nee
 ded in the foetal testis to support normal tissue function.\n\nKEYWORDS: T
 issue development\, tissue-resident macrophage\, monocytes\, testis\, live
 r sinusoidal endothelium\, haematopoiesis\, PLVAP\, transmigration
ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2023/10
 /emmi.png
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
BEGIN:DAYLIGHT
DTSTART:20230326T040000
TZOFFSETFROM:+0200
TZOFFSETTO:+0300
TZNAME:EEST
END:DAYLIGHT
END:VTIMEZONE
END:VCALENDAR