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UID:1041@bioscience.fi
DTSTART;TZID=Europe/Helsinki:20231013T120000
DTEND;TZID=Europe/Helsinki:20231013T150000
DTSTAMP:20250304T083757Z
URL:https://bioscience.fi/events/doctoral-defence-nigatu-adossa/
SUMMARY:Dissertation defence: MSc Nigatu Adossa
DESCRIPTION:MSc Nigatu Adossa defends his doctoral dissertation in Computer
  Science entitled “Computational approaches for single-cell omics and mu
 lti-omics data” at the University of Turku on 13 October 2023 at 12.00 (
 Medisiina C\, Osmo Järvi lecture hall\, Kiinamyllynkatu 10\, Turku).\n\nO
 pponent: Professor Sascha Ott (University of Warwick\, UK)\nCustos: Profes
 sor Laura Elo (University of Turku)\n\nSummary of the Doctoral Dissertatio
 n:\n\nThis thesis studied single-cell omics data analysis methods and util
 ized these to investigate the cells of the uterus. Single-cell omics techn
 ologies allow the study of tissues with single-cell resolution\, offering 
 profound insights into fundamental biology and various disease conditions.
  The first part of the thesis was dedicated to exploring methodologies in 
 single-cell tranomics. In single-cell tranome analysis\, the cell type ide
 ntification is based on accurate clustering of the cells. Consequently\, c
 lustering plays a pivotal role in the analysis pipeline. The first study o
 f the thesis compared different types of Dirichlet Process mixture models.
  This investigation underscored the value of Dirichlet process mixture mod
 els as valuable additions to the clustering analysis of single-cell tranom
 ic data. It was demonstrated that their utility is heavily dependent on th
 e characteristics of the data under examination. The second study within t
 he thesis involved an assessment of strategies and challenges related to t
 he integrative analysis of single-cell multi-omic data. This study also pr
 oposed approaches for effectively integrating different types of single-ce
 ll data\, such as tranomics\, epigenomics\, and proteomics.\n\nThe second 
 part of the thesis utilized integrative analysis of single-cell tranomics 
 to study the roles played by distinct uterine cell types in the occurrence
  of late-onset and early-onset preeclampsia\, two devastating pregnancy di
 sorders. Based on the results\, deficiencies in the differentiation of ute
 rine stromal cells are notably implicated in late-onset preeclampsia\, as 
 the activation of specific immune cells\, known as uterine natural killer 
 cells\, plays a specific role in early-onset preeclampsia. Furthermore\, t
 hrough gene regulatory network analysis of these cell types\, crucial fact
 ors governing maternal immunotolerance\, essential for a successful pregna
 ncy\, were identified. These factors may also contribute to pregnancy-rela
 ted disorders.\n\nDoctoral Dissertation at UTUPub: https://urn.fi/URN:ISBN
 :978-951-29-9450-2
ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2023/10
 /Nigatu.jpeg
CATEGORIES:Turku Bioscience Events
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