BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186907@bioscience.fi DTSTART;TZID=Europe/Helsinki:19700101T000000 DTEND;TZID=Europe/Helsinki:19700101T000000 DTSTAMP:20260419T120832Z URL: SUMMARY:Frontiers of Science: Prof. Brett Nixon DESCRIPTION:\n\nFrontiers of Science\n\nFebruary 27th at 12:00\nOnsite even t\nin Presidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Brett Nixon\, The University of Newcastle\; Hunter Medical Research Institute\, Australia\nUnderstanding the origins of health\, pathology and infertilit y through the sperm epigenome\nHost: Petra Sipilä (petra.sipila@utu.fi)\n \nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSi x PhD researchers and early-career postdocs are welcome to have a lunch an d discuss with Prof. Nixon after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections f or future. Everyone is welcome to join\, BioCity Turku will offer the lunc h.\n\nIf you got interested\, please send an email to biocityturku@bioscie nce.fi\n\n \;\n\nProfessor Brett Nixon is a Senior Research Fellow of the National Health and Medical Research Council of Australia and a Profes sor of Biology at The University of Newcastle\, Australia. In this positio n\, he serves as Director of the Priority Research Centre for Reproductive Science and of the Hunter Medical Research Institute Infertility and Repr oduction Research Program. He has conducted research activity at the basic biology / clinical andrology interface\, gaining insights into how sperm gain the function required to fertilise an egg\, and how these processes b ecome disrupted in cases of male infertility. His research also focuses on the mechanisms by which environmental and lifestyle factors impact sperm quality and the consequences of such changes for embryo development. Prof. Nixon’s research models focus primarily on the male germline\, but the implications of this research are of direct relevance to our understanding of cell biology more broadly. A defining feature of his research has been the application of advanced mass spectrometry and next-generation sequenc ing technologies to dissect changes in the proteomic and epigenomic (small non-coding RNA) landscape of sperm cells elicited by various environmenta l stressors. This work has made important contributions to our mechanistic knowledge of the pathways that both germ cells and their somatic support cells engage in responding to stressors such as xenobiotics\, oxidative st ress\, heat stress\, and chemotherapeutic agents. His current research foc uses on the mechanisms by which environmental and lifestyle factors impact sperm epigenome and the consequences of such changes for embryo developme nt. A particular focus for his current work is to translate this knowledge into rational therapeutic interventions that mitigate the risk of cellula r damage and prevent sperm dysfunction.\n\n \;\n\nSelected publication s\n\nTrigg N\, Schjenken JE\, Martin JH\, Skerrett-Byrne DA\, Smyth SP\, B ernstein IR\, Anderson AL\, Stanger SJ\, Simpson ENA\, Tomar A\, Teperino R\, Conine CC\, De Iuliis GN\, Roman SD\, Bromfield EG\, Dun MD\, Eamens A L\, Nixon B. Subchronic elevation in ambient temperature drives alteration s to the sperm epigenome and accelerates early embryonic development in mi ce. Proc Natl Acad Sci U S A. 2024 Nov 19\;121(47):e2409790121. doi: 10.10 73/pnas.2409790121.\n\nSkerrett-Byrne DA\, Anderson AL\, Bromfield EG\, Be rnstein IR\, Mulhall JE\, Schjenken JE\, Dun MD\, Humphrey SJ\, Nixon B. G lobal profiling of the proteomic changes associated with the post-testicul ar maturation of mouse spermatozoa. Cell Rep. 2022 Nov 15\;41(7):111655. d oi: 10.1016/j.celrep.2022.111655.\n\nTrigg NA\, Skerrett-Byrne DA\, Xavier MJ\, Zhou W\, Anderson AL\, Stanger SJ\, Katen AL\, De Iuliis GN\, Dun MD \, Roman SD\, Eamens AL\, Nixon B. Acrylamide modulates the mouse epididym al proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development. Cell Rep. 2021 Oct 5\;37(1):109787. d oi: 10.1016/j.celrep.2021.109787.\n\nXavier MJ\, Roman SD\, Aitken RJ\, Ni xon B. Transgenerational inheritance: how impacts to the epigenetic and ge netic information of parents affect offspring health. Hum Reprod Update. 2 019 Sep 11\;25(5):518-540. doi: 10.1093/humupd/dmz017.\n\nZhou W\, Stanger SJ\, Anderson AL\, Bernstein IR\, De Iuliis GN\, McCluskey A\, McLaughlin EA\, Dun MD\, Nixon B. Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions. BMC Biol. 2019 Apr 18\;17(1):35. doi: 10 .1186/s12915-019-0653-5. IF 7.4\n\n \;\n\nGeneral information\n\n You can download and save all the spring 2025 FoS-seminars to your calendar f rom here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration i s not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the F rontier of Science seminars\, print out the seminar diary and after the se minar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a7 0f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2025 image credits to Teemu Tuom inen: Close up photograph of soil bacteria Streptomyces colonies border.\n \n \;\n\n \; END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:19690101T000000 TZOFFSETFROM:+0200 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR