BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:1026@bioscience.fi DTSTART;TZID=Europe/Helsinki:20240502T120000 DTEND;TZID=Europe/Helsinki:20240502T130000 DTSTAMP:20250304T083757Z URL:https://bioscience.fi/events/frontiers-of-science-prof-ellen-rothenber g/ SUMMARY:POSTPONED Frontiers of Science: Prof. Ellen Rothenberg DESCRIPTION:\n\nPOSTPONED TO SEPTEMBER 12th\nOn-site event\nPresidentti aud itorium\, BioCity\n\nProf. Ellen Rothenberg\, California Institute of Tech nology\, USA\nEpigenomic and gene regulatory network mechanisms controllin g the dynamics of early T cell lineage commitment\nHost: Riitta Lahesmaa ( rilahes@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served! \n\n \;\n\nSix PhD researchers and early-career postdocs are welcome t o have a lunch in restaurant Mauno and discuss with Prof. Rothenberg after the seminar. This is a great possibility to learn hosting skills in frien dly environment and create connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, plea se send an email to biocityturku@bioscience.fi\n\n \;\n\nThe Rothenber g group studies the molecular mechanisms that are responsible for developm ental lineage choice as hematopoietic stem cells differentiate into T lymp hocytes. This is a complex process in which stem-cell multipotentiality is lost in steps that actually overlap with the initiation of T-cell specifi c differentiation events. Thus\, it offers unique insights into the nature of "stem-ness" and the distinction between activation of a development pr ogram and irreversible commitment to that program. The approaches used in the lab are a combination of in vitro developmental biology\, high-resolut ion characterization of individual cell developmental states\, and molecul ar genetics of gene regulation. The Rothenberg group focuses on identifyin g the transcription factors and signaling events that induce T-lineage gen e expression in an uncommitted precursor and determine also how they work to force the cell to relinquish other developmental options. Kinetic disse ction of this complex process using in vitro differentiation systems and r etroviral perturbation make it possible to solve the roles of individual r egulatory molecules in successive\, highly-defined developmental contexts. \n\n \;\n\nSelected publications\n\nShin B\, Zhou W\, Wang J\, Gao F\, Rothenberg EV. 2023. Runx factors launch T cell and innate lymphoid progr ams via direct and gene network-based mechanisms. Nat Immunol. 2023 Sep\;2 4(9):1458-1472. doi: 10.1038/s41590-023-01585-z\n\nRothenberg EV. 2023. Th e β-selection step shapes T-cell identity. Nature. 2023 Jan\;613(7944):44 0-442. doi: 10.1038/d41586-023-00025-0\n\nShin B\, Hosokawa H\, Romero-Wol f M\, Zhou W\, Masuhara K\, Tobin VR\, Levanon D\, Groner Y\, Rothenberg E V. 2021. Runx1 and Runx3 drive progenitor to T-lineage transcriptome conve rsion in mouse T cell commitment via dynamic genomic site switching. Proc Natl Acad Sci U S A. 2021 Jan 26\;118(4):e2019655118. doi: 10.1073/pnas.20 19655118\n\n \n\nGeneral information\n\n You can download and save all t he spring 2024 FoS-seminars to your calendar from here: https://seafile.ut u.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\ , print out the seminar diary and after the seminar ask the BioCity coordi nator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidd en.\n Spring 2024 FoS image credits to Jenny Pessa: Transformed human bre ast epithelial HS578T cells (flattened)\, labelled with commercial fluores cent antibodies. Image acquired on 3i CSU-W1 Spinning disk with 40x object ive.\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2023/12 /rothenberg-400.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR