BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186910@bioscience.fi DTSTART;TZID=Europe/Helsinki:19700101T000000 DTEND;TZID=Europe/Helsinki:19700101T000000 DTSTAMP:20260417T112235Z URL: SUMMARY:Frontiers of Science: Prof. Gareth Inman DESCRIPTION:\n\nFrontiers of Science\n\nMarch 27th at 12:00\nOnsite event\n in Presidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Gareth I nman\, Beatson Institute for Cancer Research\, UK\nDeciphering squamous ca ncer disease progression\nHost: Veli-Matti Kähäri (velkah@utu.fi)\n\nCof fee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and dis cuss with Prof. Inman after the seminar. This is a great possibility to le arn hosting skills in a friendly environment and create connections for fu ture. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\ nIf you got interested\, please send an email to biocityturku@bioscience.f i\n\n \;\n\nThe transforming growth factor beta (TGFβ) superfamily co mprises approximately forty related dimeric polypeptide cytokines includin g the bone morphogenetic proteins (BMPs)\, the growth and differentiation factors (GDFs)\, activin\, nodal and the TGFβs (TGFβ1\, TGFβ2\, TGFβ3) . As well as having vital normal physiological functions during developmen t and in adult life these factors play pivotal roles in cancer biology act ing as potent tumour suppressors or tumour promoters in a context dependen t manner. Work in Inman laboratory seeks to understand how\, when and wher e TGF superfamily signalling regulates tumour progression. Dysregulatio n of TGF signalling is particularly prevalent in squamous cell cancers and this has led the team to begin to decipher the molecular landscape of cutaneous squamous cell carcinoma and its similarities with other squamous tumour subtypes. Inman laboratory’s work focuses on understanding the d river genes\, pathways and processes that drive squamous cancer disease pr ogression with particular focus on cSCC\, Head and Neck SCC and the “squ amous” subtype of pancreatic cancer using in-vitro\, ex-vivo and in-vivo pre-clinical models.\n\n \;\n\nSelected publications\n\nKiourtis C\, Terradas-Terradas M\, Gee LM\, May S\, Georgakopoulou A\, …\, Inman GJ\, Campbell A\, Barry ST\, Quaglia A\, Morris CM\, LeBeau FEN\, Sansom OJ\, Kirschner K\, Jalan R\, Oakley F\, Bird TG. 2024 Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nat Cell Biol. 2024 Nov 13. doi: 10.1038/s41556-024-01543-3.\n\nStrathearn LS\, Spender L C\, Schoenherr C\, Mason S\, Edwards R\, Blyth K\, Inman GJ. C1orf106 (INA VA) Is a SMAD3-Dependent TGF-β Target Gene That Promotes Clonogenicity an d Correlates with Poor Prognosis in Breast Cancer. Cells. 2024 Sep 12\;13( 18):1530. doi: 10.3390/cells13181530.\n\nCarrasco G\, Stavrou I\, Treanor- Taylor M\, Beetham H\, Lee M\, Masalmeh R\, Carreras-Soldevila A\, Hardman D\, Bernabeu MO\, von Kriegsheim A\, Inman GJ\, Byron A\, Brunton VG.Onco genesis. 2024. Involvement of Kindlin-1 in cutaneous squamous cell carcino ma. 2024 Jul 9\;13(1):24. doi: 10.1038/s41389-024-00526-1.\n\nBailey P\, R idgway RA\, Cammareri P\, …\, Dimonitsas E\, Stratigos AJ\, Arron ST\, W ang J\, Blyth K\, Proby CM\, Harwood CA\, Sansom OJ\, Leigh IM\, Inman GJ. 2023. Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nat Commun. 2023 Aug 25\;14(1):5211. doi: 1 0.1038/s41467-023-40822-9.\n\nFlanagan DJ\, Amirkhah R\, Vincent DF\, Gund uz N\, …\, Lawler M\, Leedham SJ\, Barry ST\, Inman GJ\, van Rheenen J\, Dunne PD\, Sansom OJ. 2022. Epithelial TGFβ engages growth-factor signal ling to circumvent apoptosis and drive intestinal tumourigenesis with aggr essive features. Nat Commun. 2022 Dec 7\;13(1):7551. doi: 10.1038/s41467-0 22-35134-3.\n\n \;\n\nGeneral information\n\n You can download and sa ve all the spring 2025 FoS-seminars to your calendar from here: https://se afile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, parti cipation list is circulated in the audience\n If you are a student and la ter wish to get a certificate of attendance from the Frontier of Science s eminars\, print out the seminar diary and after the seminar ask the BioCit y coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2025 image credits to Teemu Tuominen: Close up photo graph of soil bacteria Streptomyces colonies border.\n\n \;\n\n \; END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:19690101T000000 TZOFFSETFROM:+0200 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR