BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.5//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:187037@bioscience.fi DTSTART;TZID=Europe/Helsinki:20261119T120000 DTEND;TZID=Europe/Helsinki:20261119T130000 DTSTAMP:20260916T122318Z URL:https://bioscience.fi/events/frontiers-of-science-prof-gwendalyn-rando lph/ SUMMARY:Frontiers of Science: Prof. Gwendalyn Randolph DESCRIPTION:19th November at 12:00\nOnsite event\nin Presidentti auditorium \, BioCity\nAutumn 2026 poster\n\nProf. Gwendalyn Randolph\, WashU Medicin e\, USA\nThe 3 L’s converge: Lymphoid tissue\, lymphatics\, and lipoprot eins\n\nHost: Sirpa Jalkanen (sirjal@utu.fi)\n\nCoffee and sandwich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have lunch and discuss with Prof. Ran dolph after the seminar. This is a great possibility to learn hosting skil ls in a friendly environment and create connections for future. Everyone i s welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got inte rested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\n Gwendalyn J. Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Lo uis\, Missouri. Her  research focuses on the trafficking of immune cells and molecular cargo between tissues\, lymphatics\, and distal organs\, and how these processes contribute to chronic inflammatory disease. Her labor atory has defined how monocytes\, dendritic cells\, macrophages\, and lipo proteins migrate through tissues and lymphatic vessels in conditions such as atherosclerosis\, psoriasis\, Crohn’s disease\, and liver inflammatio n. By combining immunology\, imaging\, lineage tracing\, and single-cell p rofiling approaches\, her lab has revealed mechanisms that regulate immune cell migration\, lymphatic transport\, and tissue-specific macrophage spe cialization. More recently\, Gwendalyn Randolph’s research has focused o n the role of high-density lipoprotein (HDL) trafficking in inflammation a nd tissue homeostasis. Her group demonstrated that lymphatic and vascular transport pathways are critical for HDL movement between organs and identi fied a specialized form of intestine-derived HDL that protects the liver f rom inflammatory injury caused by microbial products. These findings provi de new insight into the links between immunity\, metabolism\, and inflamma tory disease\, with potential translational applications for cardiovascula r\, intestinal\, and liver disorders. In parallel\, her laboratory has tra ined numerous scientists who have gone on to establish independent researc h laboratories worldwide.\n\n \;\n\nSelected publications\n\nShchukina I\, Rodriguez-Hernandez CJ\, …\, Kreisel D\, Randolph GJ\, Artyomov MN. Inflammaging in aged tissues drives remodeling of the CD8+ T cell compart ment. Cell Rep. 2026 Apr 22\;45(5):117303\n\nKim A\, Alligood DM\, …\, H egazy L\, Zinselmeyer BH\, Brestoff JR\, Martin CA\, Warner BW\, Elgendy B \, Randolph GJ. A Gut-Restricted Liver X Receptor Agonist Ameliorates Live r Injury in Experimental Short Bowel Syndrome. Gastroenterology. 2026 May\ ;170(5):1017-1032\n\nErlich EC\, Alayo QA\, Kim A\, Han J\, Mintz RL\, Huc kstep CG\, Ruiz HS\, Field RL\, Dunning TJ\, Saleh LS\, Hoofnagle MH\, Tum anov AV\, Guilak F\, Brestoff JR\, Czepielewski RS\, Randolph GJ. Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis. Nat Immunol. 2025 Oct\;26(10):1781-1793\n\nGallerand A\, Han J\, Ivanov S\, Ra ndolph GJ. Mouse and human macrophages and their roles in cardiovascular h ealth and disease. Nat Cardiovasc Res. 2024 Dec\;3(12):1424-1437\n\nHan J\ , Gallerand A\, Erlich EC\, …\, Finlay CM\, Allen JE\, Jakubzick CV\, El se KJ\, Onufer EJ\, Zhang N\, Randolph GJ. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct dis tribution between species. Nat Immunol. 2024 Jan\;25(1):155-165\n\n \; \n\nGeneral information\n\n Registration is not needed\, participation li st is circulated in the audience.\n If you are a student and later wish t o get a certificate of attendance from the Frontier of Science seminars (B KEM1020\; UTU)\, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9a d0a/\n Please note that any audio or video recording of the seminars is s trictly forbidden.\n Autumn 2026 image credits to Samuel Svärd: Whole mo unt immunofluorescent staining of the mouse retina. Image acquired on 3i C SU-W1 Spinning disk with 10x objective.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2026/09 /randolph-thumbnail.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20261025T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR