BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186964@bioscience.fi DTSTART;TZID=Europe/Helsinki:20250918T120000 DTEND;TZID=Europe/Helsinki:20250918T130000 DTSTAMP:20250916T075913Z URL:https://bioscience.fi/events/frontiers-of-science-prof-hiroki-ueda/ SUMMARY:Frontiers of Science: Prof. Hiroki Ueda DESCRIPTION:18th September at 12:00\nOnsite event\nin Presidentti auditoriu m\, BioCity\nAutumn 2025 program\n\nProf. Hiroki Ueda\, University of Toky o\, Japan\nWhy do we sleep? The role of calcium and phosphorylation in sle ep\n\nHost: Diana Lehotina (diana.lehotina@utu.fi)\n\nCoffee and sandwich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD researcher s and early-career postdocs are welcome to have a lunch and discuss with P rof. Ueda after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyo ne is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \; \n\nWhat’s one thing every human does? Sleep. Professor Ueda\, a world-r eowned neuroscientist at the University of Tokyo\, is at the forefront of uncovering the secrets behind this sacred process — why do we need sleep \, and how does our brain regulate it? What makes us fall asleep and to wa ke up? What are “wake-promoting substances”? Is there a "SOS switch" t hat cancels sleep under emergency conditions? To tackle these questions\, the lab invented cutting-edge technologies\, including CUBIC\, a groundbre aking whole-brain and whole-body tissue clearing and imaging methods and t riple-CRISPR method\, a next-generation genetic approach enabling one-step creation of knockout and knock-in mice without the need for breeding. Th eir work led to the WISE model (Wake Inhibition\, Sleep Enhancement)\, a n ew hypothesis proposing that deep sleep – rather than wakefulness – st rengthens neuronal connections. The model also explains why chronic sleep deprivation can contribute to depression and why some fast-acting antidepr essants increase deep sleep activity. As the professor will share the grou p’s research on sleep health\, we suggest you to join this lecture and g ain new insights into your own sleep!\n\n \;\n\nSelected publications\ n\nWang Y\, Cao S\, Tone D\, Fujishima H\, Yamada RG\, Ohno RI\, Shi S\, M atsuzawa K\, Yada S\, Kaneko M\, Sakamoto H\, Onishi T\, Ukai-Tadenuma M\, Ukai H\, Hanashima C\, Hirose K\, Kiyonari H\, Sumiyama K\, Ode KL\, Ueda HR. Postsynaptic competition between calcineurin and PKA regulates mammal ian sleep-wake cycles. Nature. 2024 Dec\;636(8042):412-421\n\nKon K\, Ode KL\, Mano T\, Fujishima H\, Takahashi RR\, Tone D\, Shimizu C\, Shiono S\, Yada S\, Matsuzawa K\, Yoshida SY\, Yoshida Garçon J\, Kaneko M\, Shinoh ara Y\, Yamada RG\, Shi S\, Miyamichi K\, Sumiyama K\, Kiyonari H\, Susaki EA\, Ueda HR. Cortical parvalbumin neurons are responsible for homeostati c sleep rebound through CaMKII activation. Nat Commun. 2024 Jul 18\;15(1): 6054\n\nUeda HR\, Ertürk A\, Chung K\, Gradinaru V\, Chédotal A\, Tomanc ak P\, Keller PJ. Tissue clearing and its applications in neuroscience. Na t Rev Neurosci. 2020 Feb\;21(2):61-79\n\nMurakami TC\, Mano T\, Fujishima H\, Konno A\, Watanabe TM\, Hirai H\, Ueda HR. Advanced CUBIC tissue clear ing for whole-organ cell profiling. Nat Protoc. 2019 Dec\;14(12):3506-3537 \n\nSusaki EA\, Tainaka K\, Perrin D\, Kishino F\, Tawara T\, Watanabe TM\ , Yokoyama C\, Onoe H\, Eguchi M\, Yamaguchi S\, Abe T\, Kiyonari H\, Shim izu Y\, Miyawaki A\, Yokota H\, Ueda HR. Whole-brain imaging with single-c ell resolution using chemical cocktails and computational analysis. Cell. 2014 Apr 24\;157(3):726-39\n\n \;\n\nGeneral information\n\n You can download and save all the autumn 2025 FoS-seminars to your calendar from h ere: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Fronti er of Science seminars\, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80a c1e46a9ad0a/\n Please note that any audio or video recording of the semin ars is strictly forbidden.\n Autumn 2025 image credits to Kari Kaunisto: Sahlberg family collections\, Biodiversity unit\, University of Turku\n\n& nbsp\; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/05 /ueda-500px.jpg CATEGORIES:Turku Bioscience Events LOCATION:Presidentti auditorium\, BioCity\, Tykistökatu 6A\, 20520\, Turku \, Finland GEO:60.449245;22.293052 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Tykistökatu 6A\, 20520\, T urku\, Finland;X-APPLE-RADIUS=100;X-TITLE=Presidentti auditorium\, BioCity :geo:60.449245,22.293052 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20250330T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR