BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:1025@bioscience.fi DTSTART;TZID=Europe/Helsinki:20240229T120000 DTEND;TZID=Europe/Helsinki:20240229T130000 DTSTAMP:20250304T083757Z URL:https://bioscience.fi/events/frontiers-of-science-prof-juha-klefstrom/ SUMMARY:Frontiers of Science: Prof. Juha Klefström DESCRIPTION:\n\nFebruary 29th at 12:00\nOn-site event\nPresidentti auditori um\, BioCity\nSpring 2024 program\n\nProf. Juha Klefström\, University of Helsinki\, Finland\nOf MYC\, mitochondrial metabolism and death – It’ s better to burn out than fade away\nHost: Jukka Westermarck (jukwes@utu.f i)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n \nSix PhD researchers and early-career postdocs are welcome to have a lunc h in restaurant Mauno and discuss with Prof. Klefström after the seminar. This is a great possibility to learn hosting skills in friendly environme nt and create connections for future. Everyone is welcome to join\, BioCit y Turku will offer the lunch.\n\nIf you got interested\, please send an em ail to biocityturku@bioscience.fi\n\n \;\n\nJuha Klefström is a FICAN Research Professor in Finnish Cancer Institute\, a part time Professor in FICAN-South (HUS) and a part time Research Director in the Translational Cancer Medicine Program\, Medical Faculty\, University of Helsinki. Klefst röm is an expert in translational cancer research\, breast cancer biology \, immuno-oncology\, oncogenes and tumor suppressors\, cell death\, geneti cally engineered mouse models of breast cancer\, mammary gland reconstitut ion techniques\, ex vivo explant cultures and recombinant viral gene trans fer methods. Klefström’s research focuses on therapeutic strategies aim ing to exploit oncogene-induced vulnerabilities and he has long-term inter est in the apoptotic function of MYC protein. Currently\, his research gro up explores the potential of oncogenic MYC in triggering immunogenic death of the tumor cells. Klefström’s research group has established variety of three-dimensional culture systems for mammary primary and stem cell-ba sed organotypic breast structures as well as patient tumor-derived explant s for ex vivo target validation and for studies of breast cancer developme nt and translation.\n\n \;\n\nSelected publications\n\nMunne PM\, Mart ikainen L\, Räty I\, Bertula K\, …\, Monni O\, Pouwels J\, Sahu B\, Mat tson J\, Joensuu H\, Heikkilä P\, Elo LL\, Metcalfe C\, Junttila MR\, Ikk ala O\, Klefström J. 2021. Compressive stress-mediated p38 activation req uired for ERα + phenotype in breast cancer. Nat Commun. 2021 Nov 29\; 12(1):6967. doi: 10.1038/s41467-021-27220-9\n\n \;\n\nTervonen TA\, Pa nt SM\, Belitškin D\, Englund JI\, Närhi K\, Haglund C\, Kovanen PE\, Ve rschuren EW\, Klefström J. 2021. Oncogenic Ras Disrupts Epithelial Integr ity by Activating the Transmembrane Serine Protease Hepsin. Cancer Res. 20 21 Mar 15\;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760\n\nHaikala HM\, Anttila JM\, Marques E\, …\, Mustjoki S\, Kovanen P\, Eilers M\, Le verson JD\, Klefström J. 2019. Pharmacological reactivation of MYC-depend ent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commu n. 2019 Feb 6\;10(1):620. doi: 10.1038/s41467-019-08541-2\n\n \;\n\nGe neral information\n\n You can download and save all the spring 2024 FoS-s eminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e4 6a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificat e of attendance from the Frontier of Science seminars\, print out the semi nar diary and after the seminar ask the BioCity coordinator to sign it htt ps://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2024 F oS image credits to Jenny Pessa: Transformed human breast epithelial HS578 T cells (flattened)\, labelled with commercial fluorescent antibodies. Ima ge acquired on 3i CSU-W1 Spinning disk with 40x objective.\n\n \;\n\n& nbsp\; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2023/12 /klefstrom-400.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20231029T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR