BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:187004@bioscience.fi DTSTART;TZID=Europe/Helsinki:20260423T120000 DTEND;TZID=Europe/Helsinki:20260423T130000 DTSTAMP:20260324T072534Z URL:https://bioscience.fi/events/frontiers-of-science-prof-kristian-stromg aard/ SUMMARY:Frontiers of Science: Prof. Kristian Strømgaard DESCRIPTION:23rd April 2026 at 12:00\nOnsite event\nin Presidentti auditori um\, BioCity\nSpring 2026 program\n\nProf. Kristian Strømgaard\, Universi ty of Copenhagen\, Denmark\nTargeting receptor complexes with therapeutic peptides\n\nHost: Pekka Postila (pekka.postila@utu.fi)\n\nCoffee and sandw ich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD resear chers and early-career postdocs are welcome to have a lunch and discuss wi th Prof. Strømgaard after the seminar. This is a great possibility to lea rn hosting skills in a friendly environment and create connections for fut ure. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\n If you got interested\, please send an email to biocityturku@bioscience.fi \n\n \;\n\nStrømgaard lab combines solid-phase peptide synthesis\, or ganic chemical synthesis\, and peptide microarrays with protein expression \, biochemical assays\, and biophysical techniques in order to develop mod ulators of protein-protein interactions. Examples include development of d imeric peptide-based inhibitors of PSD-95\, and super-binding peptides tar geting gephyrin.\n\nThe team employs peptide microarrays\, incorporation o f unnatural amino acids and protein semi-synthesis to address molecular de terminants of protein-protein interactions\, for instance regulation of in teractions by post-translational protein modification. Examples include si te-specific introduction of cross-linking amino acids\, backbone modificat ions\, and post-translational modifications\, in particular site-specific phosphorylation\, of therapeutically relevant proteins.\n\nStrømgaard gro up employs peptide and protein engineering to study the molecular details of protein-protein interactions (PPIs)\, and develop and design specific i nhibitors for these interactions. They develop in vivo active peptide-base d inhibitors of PPIs with putative therapeutic relevance. In parallel\, th ey also study the molecular mechanisms of these PPIs\, including the engag ement of hydrogen-bonding networks\, and regulation of PPIs by post-transl ational modifications (PTMs)\n\n \;\n\nSelected publications\n\nFan Y\ , Lyu L\, Vazquez-Uribe R\, Zhang W\, Bongers M\, …\, Kulakova A\, Wiere r M\, Harris P\, Gæde J\, Rossing P\, Knop FK\, Pers TH\, Hansen TH\, Nie lsen T\, Li L\, Strømgaard K\, Yang G\, Sommer MOA\, Pedersen O. 2025. Po lypeptides synthesized by common bacteria in the human gut improve rodent metabolism. Nat Microbiol. 2025 Aug\;10(8):1918-1939.\n\nNielsen AL\, Bart ling CRO\, Zarda A\, De Sadeleer N\, Neeser RM\, Schwaller P\, Strømgaard K\, Heinis C. 2025. Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development. Angew Chem Int Ed Engl. 2025 Jul\;64(27):e202500493\n\nGangwar SP\, Yelshanskaya MV\, Akt olun M\, Yen LY\, Newton TP\, Strømgaard K\, Kurnikova MG\, Sobolevsky AI . 2024. Trapping of spermine\, Kukoamine A\, and polyamine toxin blockers in GluK2 kainate receptor channels. Nat Commun. 2024 Nov 26\;15(1):10257.\ n\nRosenbaum MI\, Clemmensen LS\, Bredt DS\, Bettler B\, Strømgaard K. 20 20. Targeting receptor complexes: a new dimension in drug discovery. Nat R ev Drug Discov. 2020 Dec\;19(12):884-901.\n\n \;\n\nGeneral informatio n\n\n Registration is not needed\, participation list is circulated in th e audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar d iary and after the seminar ask the BioCity coordinator to sign it https:// seafile.utu.fi/f/0cd08ce7e61b419b88cb/\n Please note that any audio or vi deo recording of the seminars is strictly forbidden.\n Spring 2026 image credits to Jan Kaslin: Motor neurons (green) and newly produced cells (red ) are organized around the central canal (blue cells surrounding channel t hat crosses the image) in the adult zebrafish spinal cord. Image taken usi ng Leica SP8 confocal microscope.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/11 /fos-spring2026-thumbnail.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20260329T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR