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UID:187001@bioscience.fi
DTSTART;TZID=Europe/Helsinki:20260212T120000
DTEND;TZID=Europe/Helsinki:20260212T130000
DTSTAMP:20260204T095821Z
URL:https://bioscience.fi/events/frontiers-of-science-prof-mohamed-bentire
 s-alj/
SUMMARY:Frontiers of Science: Prof. Mohamed Bentires-Alj
DESCRIPTION:12th February at 12:00\nOnsite event\nin Presidentti auditorium
 \, BioCity\nSpring 2026 program\n\nProf. Mohamed Bentires-Alj\, University
  of Basel\, Switzerland\nBreast Tumor Heterogeneity and Metastasis: From M
 echanistic Insights to Functional Personalized Therapy\n\nHost: Jenny Pess
 a (jenny.pessa@abo.fi)\n\nCoffee and sandwich served at 11:45\, first come
  first serve!\n\n&nbsp\;\n\nSix PhD researchers and early-career postdocs 
 are welcome to have a lunch and discuss with Prof. Bentires-Alj after the 
 seminar. This is a great possibility to learn hosting skills in a friendly
  environment and create connections for future. Everyone is welcome to joi
 n\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please 
 send an email to biocityturku@bioscience.fi\n\n&nbsp\;\n\nBentires-Alj lab
  explores both cell autonomous (genetics\, epigenetics\, and proteomics) a
 nd non-cell autonomous mechanisms (immune cells\, adipcoytes\, and other s
 tromal factors). They use systems medicine quantitative methods\, syntheti
 c lethal screens\, unbiased pooled shRNA\, CRISPR\, transposon-based scree
 ns\, and hypothesis-driven approaches. Computational biology is a very imp
 ortant part of their research. Moreover\, the team uses multiphoton intrav
 ital imaging to assess the interactions between cancer cells and immune ce
 lls.\n\nThese interdisciplinary projects seek to elucidate the integrated 
 effects of signaling pathways and epigenetics on breast cell fate and tumo
 r heterogeneity\, and to leverage this mechanistic understanding into ther
 apy. To this end\, Bentires-Alj lab collaborates with clinicians and have 
 built a Breast Cancer Personalized Medicine Team which should ultimately i
 mprove treatment for patients in Basel and throughout the world.\n\n&nbsp\
 ;\n\nSelected publications\n\nHamelin\, B.\, Obradović\, M. M. S.\, Sethi
 \, A.\, Kloc\, M.\, Münst\, S.\, Beisel\, C.\, Eschbach\, K.\, Kohler\, H
 .\, Soysal\, S.\, Vetter\, M.\, Weber\, W. P.\, Stadler\, M. B.\, &amp\; B
 entires-Alj\, M. (2023). Single-cell Analysis Reveals Inter- and Intratumo
 ur Heterogeneity in Metastatic Breast Cancer. Journal of mammary gland bio
 logy and neoplasia\, 28(1)\, 26. https://doi.org/10.1007/s10911-023-09551-
 z\n\nCouto\, J. P.\, Vulin\, M.\, Jehanno\, C.\, Coissieux\, M. M.\, Hamel
 in\, B.\, Schmidt\, A.\, Ivanek\, R.\, Sethi\, A.\, Bräutigam\, K.\, Frei
 \, A. L.\, Hager\, C.\, Manivannan\, M.\, Gómez-Miragaya\, J.\, Obradovi
 ć\, M. M.\, Varga\, Z.\, Koelzer\, V. H.\, Mertz\, K. D.\, &amp\; Bentire
 s-Alj\, M. (2023). Nicotinamide N-methyltransferase sustains a core epigen
 etic program that promotes metastatic colonization in breast cancer. The E
 MBO journal\, 42(13)\, e112559. https://doi.org/10.15252/embj.2022112559\n
 \nVulin\, M.\, Jehanno\, C.\, Sethi\, A.\, Correia\, A. L.\, Obradović\, 
 M. M. S.\, Couto\, J. P.\, Coissieux\, M. M.\, Diepenbruck\, M.\, Preca\, 
 B. T.\, Volkmann\, K.\, der Maur\, P. A.\, Schmidt\, A.\, Münst\, S.\, Sa
 uteur\, L.\, Kloc\, M.\, Palafox\, M.\, Britschgi\, A.\, Unterreiner\, V.\
 , Galuba\, O.\, Claerr\, I.\, … Bentires-Alj\, M. (2022). A high-through
 put drug screen reveals means to differentiate triple-negative breast canc
 er. Oncogene\, 41(39)\, 4459–4473. https://doi.org/10.1038/s41388-022-02
 429-0\n\nCorreia\, A. L.\, Guimaraes\, J. C.\, Auf der Maur\, P.\, De Silv
 a\, D.\, Trefny\, M. P.\, Okamoto\, R.\, Bruno\, S.\, Schmidt\, A.\, Mertz
 \, K.\, Volkmann\, K.\, Terracciano\, L.\, Zippelius\, A.\, Vetter\, M.\, 
 Kurzeder\, C.\, Weber\, W. P.\, &amp\; Bentires-Alj\, M. (2021). Hepatic s
 tellate cells suppress NK cell-sustained breast cancer dormancy. Nature\, 
 594(7864)\, 566–571. https://doi.org/10.1038/s41586-021-03614-z\n\n&nbsp
 \;\n\nGeneral information\n\n 	Registration is not needed\, participation 
 list is circulated in the audience\n 	If you are a student and later wish 
 to get a certificate of attendance from the Frontier of Science seminars\,
  print out the seminar diary and after the seminar ask the BioCity coordin
 ator to sign it https://seafile.utu.fi/f/0cd08ce7e61b419b88cb/\n 	Please n
 ote that any audio or video recording of the seminars is strictly forbidde
 n.\n 	Spring 2026 image credits to Jan Kaslin: Motor neurons (green) and n
 ewly produced cells (red) are organized around the central canal (blue cel
 ls surrounding channel that crosses the image) in the adult zebrafish spin
 al cord. Image taken using Leica SP8 confocal microscope.\n\n&nbsp\;
ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/11
 /fos-spring2026-thumbnail.jpg
CATEGORIES:Turku Bioscience Events
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