BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186911@bioscience.fi DTSTART;TZID=Europe/Helsinki:19700101T000000 DTEND;TZID=Europe/Helsinki:19700101T000000 DTSTAMP:20260508T094152Z URL: SUMMARY:Frontiers of Science: Prof. Sampsa Hautaniemi DESCRIPTION:\n\nFrontiers of Science\n\nApril 3rd at 12:00\nOnsite event\ni n Presidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Sampsa Ha utaniemi\, University of Helsinki\nCharacterizing and overcoming chemother apy resistance in ovarian cancer\nHost: Jukka Westermarck (jukwes@utu.fi)\ n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nS ix PhD researchers and early-career postdocs are welcome to have a lunch a nd discuss with Prof. Hautaniemi after the seminar. This is a great possib ility to learn hosting skills in a friendly environment and create connect ions for future. Everyone is welcome to join\, BioCity Turku will offer th e lunch.\n\nIf you got interested\, please send an email to biocityturku@b ioscience.fi\n\n \;\n\nHautaniemi team conducts research to understand and overcome drug resistance in cancer. They use patient-derived multi-mo dal data\, such as histopathology images\, DNA/RNA/DNA methylation sequenc ing data\, circulating tumor DNA\, radiological images\, clinical data and ex vivo data collected from observational\, longitudinal and multi-region trial (DECIDER\; ClinicalTrials ID: NCT04846933) to characterize chemothe rapy resistance mechanisms in ovarian high grade serous carcinoma. The ult imate goal of their cross-disciplinary research is to translate these mult i-modal data into testable predictions and further into benefits in cancer patient care.\n\n \;\n\nSelected publications\n\nLahtinen A\, Lavikka K\, Virtanen A\, Li Y\, …\,  Senkowski W\, Kallunki T\, Häkkinen A\, Hynninen J\, Oikkonen J\, Hautaniemi S. Evolutionary states and trajectori es characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma. Cancer Cell. 2023 May 11:S1535-6108(23)00143-5.\n\ nZhang K\, Erkan EP\, Jamalzadeh S\, …\, Häkkinen A\, Hautaniemi S\, V ähärautio A. Longitudinal single-cell RNA-seq analysis reveals stress-pr omoted chemoresistance in metastatic ovarian cancer. Science Advances. 202 2 Feb 25\;8(8).\n\nHäkkinen A\, Zhang K\, Alkodsi A\, …\,  Hietanen S\ , Lehtonen R\, Hautaniemi S. PRISM: recovering cell-type-specific expressi on profiles from individual composite RNA-seq samples. Bioinformatics. 202 1 Sep 29\;37(18):2882-2888.\n\nJamalzadeh S\, Häkkinen A\, Andersson N\, Huhtinen K\, Laury A\, Hietanen S\, Hynninen J\, Oikkonen J\, Carpén O\, Virtanen A\, Hautaniemi S. QuantISH: RNA in situ hybridization image analy sis framework for quantifying cell type-specific target RNA expression and variability. Laboratory Investigation. 2022 Jul\;102(7):753-761.\n\nOikko nen J\, Zhang K\, Salminen L\, Schulman I\, Lavikka K\, Andersson N\, Ojan perä E\, Hietanen S\, Grénman S\, Lehtonen R\, Huhtinen K\, Carpén O\, Hynninen J\, Färkkilä A\, Hautaniemi S. Prospective longitudinal ctDNA w orkflow reveals clinically actionable alterations in ovarian cancer. JCO P recision Oncology\, 2019 :3\, 1-12.\n\n \;\n\nGeneral information\n\n You can download and save all the spring 2025 FoS-seminars to your calend ar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registrati on is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from t he Frontier of Science seminars\, print out the seminar diary and after th e seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/ 44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Spring 2025 image credits to Teemu Tuominen: Close up photograph of soil bacteria Streptomyces colonies borde r.\n\n \;\n\n \; END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:19690101T000000 TZOFFSETFROM:+0200 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR