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UID:186972@bioscience.fi
DTSTART;TZID=Europe/Helsinki:20251204T120000
DTEND;TZID=Europe/Helsinki:20251204T130000
DTSTAMP:20250916T080345Z
URL:https://bioscience.fi/events/frontiers-of-science-prof-sara-wickstrom/
SUMMARY:Frontiers of Science: Prof. Sara Wickström
DESCRIPTION:4th December at 12:00\nOnsite event\nin Presidentti auditorium\
 , BioCity\nAutumn 2025 program\n\nProf. Sara Wickström\, University of He
 lsinki\, Finland\nMechanical regulation of cell states\n\nHost: Jenny Pess
 a (jenny.pessa@abo.fi)\n\nCoffee and sandwich served at 11:45\, first come
  first serve!\n\n&nbsp\;\n\nSix PhD researchers and early-career postdocs 
 are welcome to have a lunch and discuss with Prof. Wickström after the se
 minar. This is a great possibility to learn hosting skills in a friendly e
 nvironment and create connections for future. Everyone is welcome to join\
 , BioCity Turku will offer the lunch.\n\nIf you got interested\, please se
 nd an email to biocityturku@bioscience.fi\n\n&nbsp\;\n\nThe Wickström lab
  combines state-of-the-art scale-bridging technologies from nanoscale atom
 ic force microscopy and next-generation sequencing to novel ex vivo tissue
  culture methods\, the whole organism live imaging and in silico modeling 
 all the way up to analysis of the clinical patient material. The research 
 is highly interdisciplinary and involves collaborations with mathematician
 s\, physicists\, and clinical oncologists. Recent work from the Wickström
  group has uncovered how a generation of cellular forces is important for 
 controlling stem cell fate and coordinating cell fate with cell position w
 ithin the tissue. Furthermore\, the laboratory has discovered how extrinsi
 c forces generated by the tissue impact chromatin structure and epigenetic
  gene silencing\, thereby controlling the transcriptional state and lineag
 e commitment of stem cells.\n\n&nbsp\;\n\nSelected publications\n\nKoester
  J\, Miroshnikova YA\, Ghatak S\, Chacón-Martínez CA\, Morgner J\, Li X\
 , Atanassov I\, Koch M\, Bloch W\, Bartusel M\, Niessen CM\, Rada-Iglesias
  A\, Wickström SA. (2021) Niche stiffening compromises stem cell potentia
 l during aging by reducing chromatin accessibility at bivalent promoters. 
 Nat Cell Biol 7\, 771-781.\n\nNava MM\, Miroshnikova YA\, Biggs LC\, White
 field DB\, Metge F\, Boucas J\, Vihinen H\, Jokitalo E\, Li X\, García Ar
 cos JM\, Hoffmann B\, Merkel R\, Niessen CM\, Dahl KN\, Wickström SA. (20
 20) Heterochromatin-driven nuclear softening protects the genome against m
 echanical stress-induced damage Cell\, 181\, 800-817\n\nKim CS\, Ding X\, 
 Allmeroth K\, Biggs\, LC\, Kolenc OI\, L’Hoest N\, Chacón-Martínez CA\
 , Edlich-Muth C\, Giavalisco P\, Quinn KP\, Denzel M\, Eming SA\, Wickstr
 öm SA. (2020) Glutamine metabolism controls stem cell fate reversibility 
 and long-term maintenance in the hair follicle. Cell Metabolism 32\, 629-6
 42.e8\n\nMiroshnikova YA\, Le HQ\, Schneider D\, Thalheim T\, Rübsam M\, 
 Bremicker N\, Polleux J\, Höppner N\, Tarantola M\, Wang I\, Balland M\, 
 Niessen CM\, Galle J\, Wickström SA. (2018). Adhesion forces and cortical
  tension couple cell proliferation and differentiation to drive epidermal 
 stratification. Nat Cell Biol 20\, 69-80.\n\n&nbsp\;\n\nGeneral informatio
 n\n\n 	You can download and save all the autumn 2025 FoS-seminars to your 
 calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n 	Regi
 stration is not needed\, participation list is circulated in the audience\
 n 	If you are a student and later wish to get a certificate of attendance 
 from the Frontier of Science seminars\, print out the seminar diary and af
 ter the seminar ask the BioCity coordinator to sign it https://seafile.utu
 .fi/d/44a70f80ac1e46a9ad0a/\n 	Please note that any audio or video recordi
 ng of the seminars is strictly forbidden.\n 	Autumn 2025 image credits to 
 Kari Kaunisto: Sahlberg family collections\, Biodiversity unit\, Universit
 y of Turku\n\n&nbsp\;
ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/05
 /wickstrom-500px.jpg
CATEGORIES:Turku Bioscience Events
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