BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186970@bioscience.fi DTSTART;TZID=Europe/Helsinki:20251106T120000 DTEND;TZID=Europe/Helsinki:20251106T130000 DTSTAMP:20250916T080250Z URL:https://bioscience.fi/events/frontiers-of-science-prof-silvia-giordano / SUMMARY:Frontiers of Science: Prof. Silvia Giordano DESCRIPTION:6th November at 12:00\nOnsite event\nin Presidentti auditorium\ , BioCity\nAutumn 2025 program\n\nProf. Silvia Giordano\, University of To rino Medical School\, Italy\nGastric cancer in the age of precision oncolo gy: new opportunities to improve treatment\n\nHost: Silvia Gramolelli (Sil via.Gramolelli@abo.fi)\n\nCoffee and sandwich served at 11:45\, first come first serve!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Giordano after the semi nar. This is a great possibility to learn hosting skills in a friendly env ironment and create connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nAltered regulation o f tyrosine kinase receptors is frequent in solid tumors and it is often as sociated with the acquisition of an aggressive phenotype. Thus\, therapies targeting these receptors have been proposed as molecular approaches to t reat human cancers. The main problem with these therapies is the onset of resistance\, which leads to treatment failure. It is therefore important t o understand the mechanisms of resistance to molecular targeted therapies\ , in an effort to optimize the outcome of the treatments. Giordano group a ims to study the molecular mechanisms that allow tumor cells to become ins ensitive to molecular targeted therapies. They focus on the study of gastr ic cancer that is the world’s third leading cause of cancer mortality. G iordano lab generated a platform of more than 70 patient-derived xenograft s (PDXs) that recapitulate the heterogeneity of this disease. Giordano lab aims to genetically dissect the gastric tumor landscape in order to inves tigate mechanisms involved in sensitivity/resistance to targeted therapies against receptor tyrosine kinases.\n\n \;\n\nSelected publications\n\ nHeat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter. Cutrone L\, Djupenström H\, Peltonen J\, Martinez Klimova E\, Corso S\, Giordano S\, Sistonen L\, Gramolelli S. PLoS Pathog. 2025 Apr 17\;21(4):e1013108\n\nBRC A2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibito rs. Petrelli A\, Rizzolio S\, …\, Degiuli M\, Baiocchi GL\, Amisano MF\, Ferrero A\, Marchiò C\, Corso S\, Giordano S. Cancer Res. 2023 May 15\;8 3(10):1699-1710\n\nBiological and targeting differences between the rare K RAS A146T and canonical KRAS mutants in gastric cancer models. Puliga E\, De Bellis C\, Vietti Michelina S\, Capeloa T\, Migliore C\, Orrù C\, Baio cchi GL\, De Manzoni G\, Pietrantonio F\, Reddavid R\, Fumagalli Romario U \, Ambrogio C\, Corso S\, Giordano S. Gastric Cancer. 2024 May\;27(3):473- 483\n\nHER2 Copy Number and Resistance Mechanisms in Patients with HER2-po sitive Advanced Gastric Cancer Receiving Initial Trastuzumab-based Therapy in JACOB Trial. Pietrantonio F\, Manca P\, Bellomo SE\, Corso S\, Raimond i A\, Berrino E\, Morano F\, Migliore C\, Niger M\, Castagnoli L\, Pupa SM \, Marchiò C\, Di Bartolomeo M\, Restuccia E\, Lambertini C\, Tabernero J \, Giordano S. Clin Cancer Res. 2023 Feb 1\;29(3):571-580\n\n \;\n\nGe neral information\n\n You can download and save all the autumn 2025 FoS-s eminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e4 6a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificat e of attendance from the Frontier of Science seminars\, print out the semi nar diary and after the seminar ask the BioCity coordinator to sign it htt ps://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictly forbidden.\n Autumn 2025 i mage credits to Kari Kaunisto: Sahlberg family collections\, Biodiversity unit\, University of Turku\n\n \; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/05 /giordano-500px.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20251026T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR