BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186908@bioscience.fi DTSTART;TZID=Europe/Helsinki:19700101T000000 DTEND;TZID=Europe/Helsinki:19700101T000000 DTSTAMP:20260419T113547Z URL: SUMMARY:Frontiers of Science: Prof. Simon Robson DESCRIPTION:\n\nFrontiers of Science\n\nMarch 6th at 12:00\nOnsite event\ni n Presidentti auditorium\, BioCity\nSpring 2025 program\n\nProf. Simon Rob son\, Harvard Medical School\, USA\nReciprocal targeting of ENTPD/CD39 ec tonucleotidases to inflame tumors and restore homeostasis\nHost: Gennady Y egutkin (genyeg@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are w elcome to have a lunch and discuss with Prof. Robson after the seminar. Th is is a great possibility to learn hosting skills in a friendly environmen t and create connections for future. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an ema il to biocityturku@bioscience.fi\n\n \;\n\nSimon Robson is a globally recognized leader in the field of purinergic signaling\, holds the prestig ious Charlotte F. and Irving W. Rabb Professorship of Medicine in Harvard and serves as Vice Chair of Research in the Department of Anesthesia\, Cri tical Care at Beth Israel Deaconess Medical Center. Dr. Robson’s pioneer ing work on ectonucleotidases\, particularly CD39\, has revealed its cruci al roles in T cells and endothelial cells\, with broad implications for ch ronic inflammatory diseases\, cancer\, and transplantation. His foundation al discoveries have had substantial translational impact\, with ongoing cl inical trials exploring CD39-targeted therapies for cancer. His current re search continues to expand knowledge of purinergic signaling in immune-rel ated diseases\, including cancer and inflammatory bowel disease\, with pro mising potential for clinical application. Dr. Robson’s combined scienti fic and medical expertise makes his talk highly relevant to both scientist s and clinicians.\n\n \;\n\nSelected publications\n\nFeng L\, Zhang H\ , Mao C\, De Andrade Mello P\, Stroopinsky D\, Csizmadia E\, Zhou J\, Avig an D\, Yu J\, Gao W\, Robson SC. Cd39 and P2rx7-Wnt signaling enhance blas t pathogenicity in an experimental model of acute myeloid leukemia. Haemat ologica. 2024 Aug 15. doi: 10.3324/haematol.2024.285547.\n\nVignali PD DeP eaux K\, Watson MJ\, Ye C\, Ford BR\, Lontos K\, McGaa NK\, Scharping NE\, Menk AV\, Robson SC\, Poholek AC\, Rivadeneira DB\, Delgoffe GM. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit an titumor immunity. Nat Immunol. 2023 Feb\;24(2):267-279. doi: 10.1038/s4159 0-022-01379-9.\n\nZhang H\, Feng L\, de Andrade Mello P\, Mao C\, Near R\, Csizmadia E\, Chan LL\, Enjyoji K\, Gao W\, Zhao H\, Robson SC. Glycoengi neered anti-CD39 promotes anticancer responses by depleting suppressive ce lls and inhibiting angiogenesis in tumor models. J Clin Invest. 2022 Jul 1 \;132(13):e157431. doi: 10.1172/JCI157431.\n\nSandhu B\, Perez-Matos MC\, Tran S\, Singhal G\, Syed I\, Feldbrügge L\, Mitsuhashi S\, Pelletier J\, Huang J\, Yalcin Y\, Csizmadia E\, Tiwari-Heckler S\, Enjyoji K\, Sévign y J\, Maratos-Flier E\, Robson SC\, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolis m. Metabolism. 2021 May\;118:154731. doi: 10.1016/j.metabol.2021.154731.\n \nHarshe RP\, Xie A\, Vuerich M\, Frank LA\, Gromova B\, Zhang H\, Robles RJ\, Mukherjee S\, Csizmadia E\, Kokkotou E\, Cheifetz AS\, Moss AC\, Kota SK\, Robson SC\, Longhi MS. Endogenous antisense RNA curbs CD39 expressio n in Crohn's disease. Nat Commun. 2020 Nov 18\;11(1):5894. doi: 10.1038/s4 1467-020-19692-y.\n\nDwyer KM\, Kishore BK\, Robson SC. Conversion of extr acellular ATP into adenosine: a master switch in renal health and disease. Nat Rev Nephrol. 2020 Sep\;16(9):509-524. doi: 10.1038/s41581-020-0304-7. \n\n \;\n\nGeneral information\n\n You can download and save all the spring 2025 FoS-seminars to your calendar from here: https://seafile.utu.f i/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation li st is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, p rint out the seminar diary and after the seminar ask the BioCity coordinat or to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please not e that any audio or video recording of the seminars is strictly forbidden. \n Spring 2025 image credits to Teemu Tuominen: Close up photograph of so il bacteria Streptomyces colonies border.\n\n \;\n\n \; END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:19690101T000000 TZOFFSETFROM:+0200 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR