BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.12//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:187039@bioscience.fi DTSTART;TZID=Europe/Helsinki:20261210T120000 DTEND;TZID=Europe/Helsinki:20261210T140000 DTSTAMP:20261104T113537Z URL:https://bioscience.fi/events/frontiers-of-science-prof-thomas-helleday / SUMMARY:Frontiers of Science and LUNCH: Prof. Thomas Helleday DESCRIPTION:10th December at 12:00 and free lunch at 13:00\nOnsite event\ni n Presidentti auditorium\, BioCity\nAutumn 2026 poster\n\nProf. Thomas Hel leday\, Karolinska Institutet\, Sweden\nTargeting cancer by oncogenic trap ping: From bench to clinical trials\n\nHost: Jukka Westermarck (jukka.west ermarck@utu.fi)\n\nNo coffees nor sandwiches\, but lunch for 150 first one s to sign up\, right after the FoS talk\, in BioCity lobby\, as a thank yo u for being active members of BioCity Turku. Everyone is welcome to join\, register here: https://link.webropolsurveys.com/S/D6C3D85639FBE114\n\nSix PhD researchers and early-career postdocs are welcome to share a lunch ta ble and discuss with Prof. Helleday after the seminar. This is a great pos sibility to learn hosting skills in a friendly environment and create conn ections for future. If you got interested\, please send an email to biocit yturku@bioscience.fi\n\n \;\n\nThomas Helleday is a Professor of Chemi cal Biology in Karolinska Institutet\, Sweden. In his research\, he is foc using on exploiting the weaknesses of cancer cells in DNA repair and alter ed metabolism. His research group uses genetic tools and develops probes t o study identified target proteins more closely. By selectively inhibiting DNA repair or proteins that are crucial for the growth of cancer cells\, the researchers tailor new treatment methods against cancer.\n\n \;\n\ nSelected publications\n\nMortusewicz O\, Haslam J\, Gad H\, Helleday T. U racil-induced replication stress drives mutations\, genome instability\, a nti-cancer treatment efficacy\, and resistance. Mol Cell. 2025 May 15\;85( 10):1897-1906\n\nGreen AC\, Marttila P\, Kiweler N\, …\, Sandberg L\, Fr ödin M\, Moussay E\, Slipicevic A\, Letellier E\, Paggetti J\, Sørensen CS\, Helleday T\, Henriksson M\, Meiser J. Formate overflow drives toxic f olate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Apr\;5(4) :642-659.\n\nMarklund M\, Schultz N\, Friedrich S\, Berglund E\, Tarish F\ , Tanoglidi A\, Liu Y\, Bergenstråhle L\, Erickson A\, Helleday T\, Lamb AD\, Sonnhammer E\, Lundeberg J. Spatio-temporal analysis of prostate tumo rs in situ suggests pre-existence of treatment-resistant clones. Nat Commu n. 2022 Sep 17\;13(1):5475\n\nMichel M\, Benítez-Buelga C\, Calvo PA\, …\, Vilotijevic I\, Kalderén C\, Osorio A\, Perona R\, Stolz A\, Stenma rk P\, Berglund UW\, de Vega M\, Helleday T. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Scie nce. 2022 Jun 24\;376(6600):1471-1476\n\n \;\n\nGeneral information\n\ n Registration is not needed\, participation list is circulated in the au dience.\n If you are a student and later wish to get a certificate of att endance from the Frontier of Science seminars (BKEM1020\; UTU)\, print out the seminar diary and after the seminar ask the BioCity coordinator to si gn it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that a ny audio or video recording of the seminars is strictly forbidden.\n Autu mn 2026 image credits to Samuel Svärd: Whole mount immunofluorescent stai ning of the mouse retina. Image acquired on 3i CSU-W1 Spinning disk with 1 0x objective.\n\n \; ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2026/09 /helleday-thumbnail.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20261025T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR