BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.2.3.1//EN
TZID:Europe/Helsinki
X-WR-TIMEZONE:Europe/Helsinki
BEGIN:VEVENT
UID:186925@bioscience.fi
DTSTART;TZID=Europe/Helsinki:19700101T000000
DTEND;TZID=Europe/Helsinki:19700101T000000
DTSTAMP:20260421T105103Z
URL:
SUMMARY:MIST Guest Seminar: Maheswara Reddy Emani
DESCRIPTION:MIST Guest Seminar\n\nMarch 31st\, 2025\, at 15.00-16.00\n\nSä
 ätiö sali\, Medisiina D\, 1. floor\n\nMaheswara Reddy Emani\, Ph.D. Prin
 cipal Scientist / Group Leader\, Genentech\, California\,USA: iPSC-derived
  Complex models for Drug Discovery\n\nHost: Riitta Lahesmaa ( rilahes@utu.
 fi )\n\nOrganizers: MIST Research Program\, Turku Bioscience Centre\n\n***
 \n\nMaheswara Reddy Emani is principal scientist and group leader at Genen
 tech (a member of Roche) since 2020. He did his  PhD in biotechnology at 
 the National Center for Cell Sciences (NCCS) at the University of Pune\, I
 ndia and in 2010\, he joined Professor Riitta Lehesmaa’s laboratory at T
 urku Biosciences in Turku\, Finland\, as a postdoctoral fellow.\n\nAt Gene
 ntech Mahesh leads his team on use of iPSC derived target cells and organo
 ids for in vitro pharmacology. These tools have proved invaluable for iden
 tifying promising lead molecules and conducting mechanistic and toxicologi
 cal studies. He is thrilled to be part of an environment committed to cond
 ucting science at the highest level and transforming these scientific disc
 overies into therapeutic solutions that can significantly benefit patients
 .\n\nSelected publications:\n\n 	Subramanian\, A*.\, Sidhom\, E*.\, Mahesw
 arareddy Emani*. et al.Single cell census of human kidney organoids shows
  reproducibility and diminished off-target cells after transplantation. N
 at Commun 10\, 5462 (2019) doi:10.1038/s41467-019-13382-0. * Equal Contr
 ibution.\n 	Moran Dvela-Levitt\, Maria Kost-Alimova\, Maheswarareddy Emani
 \, ………Todd R. Golub\, Eric S. Lander\, Anna Greka. Small molecule ta
 rgets TMED9 and promotes lysosomal degradation to reverse proteinopathy.  
 2019.\n 	Maheswarareddy Emani\, Närvä E\, ..… Lahesmaa R. The L1TD1
  protein interactome reveals the importance of post-transcriptional regu
 lation in human pluripotency. Stem Cell Reports. 2015 Mar 10\;4(3):519
 -28.\n 	Närvä E*\, Rahkonen N*\, Maheswarareddy Emani*\,.. Lahesmaa R. R
 NA-binding proteinL1TD1 interacts with LIN28 via RNA and is required for 
 human embryonic stem cell self-renewal and cancer cell proliferation. Stem
  Cells. Stem Cells. 2012 Mar\;30(3):452-60. * These authors contributed eq
 ually to this article.\n 	Dominguez SL…. Maheswarareddy Emani\, ….\, E
 aston A. TMEM106B reduction does not rescue GRN deficiency in iPSC-derived
  human microglia and mouse models. 2023 Oct 29\;26(11):108362.\n 	AmyWeste
 rling-Bui\, …..Maheswarareddy Emani\, ……… Peter  A translatio
 nal kidney organoid system bolsters human relevance of clinical developmen
 t candidate Science Advances · Jul 6\, 2022.\n\n&nbsp\;
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
BEGIN:STANDARD
DTSTART:19690101T000000
TZOFFSETFROM:+0200
TZOFFSETTO:+0200
TZNAME:EET
END:STANDARD
END:VTIMEZONE
END:VCALENDAR