BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186917@bioscience.fi DTSTART;TZID=Europe/Helsinki:19700101T000000 DTEND;TZID=Europe/Helsinki:19700101T000000 DTSTAMP:20260423T103422Z URL: SUMMARY:Immunology Seminar: Iivo Hetemäki DESCRIPTION:Immunology Seminar: Iivo Hetemäki\nMarch 4th at 14-15 (Finland time)\n\nVirtual event\n\nFlyer\n\nDr.  Iivo Hetemäki\, National Instit ute of Allergy and Infectious Diseases\, US: Immune dysregulation in patie nts with IKZF2 (Helios) deficiency\n\nRegister for the Immunology Seminar Series email list to get calendar invitation to the online seminar: https: //link.webropolsurveys.com/S/D29C32AA6E8A2F7A\n\nHost: Professor Riitta La hesmaa ( rilahes@utu.fi )\n\nImmunology seminar series is jointly organise d by the Finnish Society for Immunology\, InFLAMES Flagship and Turku Bios cience. For further information contact Anne Lahdenperä  ( ankahy@utu.fi ) or Riitta Lahesmaa ( rilahes@utu.fi )\, University of Turku.\n\n****\n\ nIivo Hetemäki is a physician-scientist with long interest in lymphocyte biology especially in inborn errors of immunity (IEI). He did his PhD thes is “Regulation of the Germinal Centre Reaction in Inborn Errors of Immun ity” under the supervision of Petteri Arstila and Eliisa Kekäläinen in Helsinki University. In his thesis he examined regulation of adaptive imm une responses and factors underlying rise of neutralizing anti-interferon antibodies in two inborn error of immunity AIRE deficiency Autoimmune Poly endocrinopathy Candidiasis Ectodermal Dystropyhy (APECED) and IKZF2 (encod ing for Helios) loss of function mutation. The report by Hetemäki &\; al. was first IKZF2 deficiency described in men. For his thesis Hetemäki received the PhD thesis award from Immunology by Finnish Society of Immuno logy. Currently\, Hetemäki is continuing postdoctoral research at the Nat ional Institutes of Health under the supervision of Mihalis Lionakis. He h as also worked as physician treating patients with IEI.\n\nSelected public ations:\n\nHetemäki I\, Kaustio M\, Kinnunen M\, Heikkilä N…\, Kekäl äinen E. Loss-of-function mutation in IKZF2 leads to immunodeficiency w ith dysregulated germinal center reactions and reduction of MAIT cells. Sc i Immunol. 2021 26\;6(65)\n\nHetemäki I\, Arstila TP\, Kekäläinen E. He lios-Illuminating the way for lymphocyte self-control. Immunology. 2024\n\ nHetemäki I\, Sarkkinen J\, Heikkilä N\, &\; al. Dysregulated germina l centre reaction with expanded T follicular helper cells in APECED lymph nodes. J Allergy Clin Immunol. 2023\n\nHetemäki\, I.\, Laakso\, S.\, Väl imaa\, H.\, Kleino\, I.\, Kekäläinen\, E.\, Mäkitie\, O.\, Arstitila\, TP. Patients with autoimmune polyendocrine syndrome type 1 have an increas ed susceptibility to severe herpesvirus infections. Clin Immunol. 2021\n\n  \;\n\n \; END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:19690101T000000 TZOFFSETFROM:+0200 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR