BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Helsinki X-WR-TIMEZONE:Europe/Helsinki BEGIN:VEVENT UID:186983@bioscience.fi DTSTART;TZID=Europe/Helsinki:20251007T140000 DTEND;TZID=Europe/Helsinki:20251007T150000 DTSTAMP:20250922T071652Z URL:https://bioscience.fi/events/immunology-seminar/ SUMMARY:Immunology Seminar\, Susanna Fagerholm DESCRIPTION:October 7th at 14-15 (Finland time)\n\nVirtual event\n\nFlyer\n \nSusanna Fagerholm\, University of Helsinki: Dendritic cell mechanical im mune memory\n\n\nRegister for the Immunology Seminar Series email list to get calendar invitation to the online seminar: https://link.webropolsurvey s.com/S/D29C32AA6E8A2F7A\n\nHost: Professor Riitta Lahesmaa ( rilahes@utu. fi )\n\nImmunology seminar series is jointly organised by the Finnish Soci ety for Immunology\, InFLAMES Flagship and Turku Bioscience. For further i nformation contact Anne Lahdenperä  ( ankahy@utu.fi ) or Riitta Lahesmaa ( rilahes@utu.fi )\, University of Turku.\n\n***\n\nSusanna Fagerholm is Professor of Cell and Molecular Biology at Faculty of Bio- and Environment al Sciences\, University of Helsinki. She heads the Integrins in immunity research group. The group’s current main research interest lays in inves tigating how mechanical interactions of myeloid immune cells with their ti ssue microenvironment regulates their function. We focus mainly on dendrit ic cells\, the main antigen presenting cells of the immune system. We prop ose that cellular interactions with the microenvironment play more importa nt roles in regulating immune cell programming than previously thought\, t hrough so called “mechanical immune memory”. The immune cell “rememb ers” its mechanical interactions with the environment through epigenetic and metabolic effects\, which impacts on immune cell gene expression\, pr ogramming and cell function. Loss of cell adhesion to the microenvironment may constitute a new “danger signal” that induces myeloid cell reprog ramming and increased immune responses in vivo.\n\nReferences\n1. Harjunp ää H\, Somermäki R\, Saldo Rubio G\, Fusciello M\, Feola S\, Faisal I\, Nieminen AI\, Wang L\, Llort Asens M\, Zhao H\, Eriksson O\, Cerullo V\, &\; Fagerholm SC. 2024. Loss of β2-integrin function results in metabo lic reprogramming of dendritic cells\, leading to increased dendritic cell functionality and anti-tumor responses. OncoImmunology\, 13(1):2369373\n2 . Harjunpää H\, Tallberg R\, Cui Y\, Guenther C\, Liew HK\, Seelbach A\, Saldo Rubio G\, Airavaara M\, Fagerholm SC. 2024. β2-Integrins Regulate Microglial Responses and the Functional Outcome of Hemorrhagic Stroke In V ivo. J Immunol. 213(4):519-525.\n3. Fagerholm SC. 2022. Integrins in healt h and diseases. New Engl J Med. 387:1519-1521.\n4. Guenther C\, Faisal I\, Fusciello M\, Sokolova M\, Ilander M\, Harjunpää H\, Tallberg R\, Varti ainen M\, Gonzalez-Granado J-M\, Alon R\, Cerullo V\, Fagerholm SC. 2021. β2-integrin adhesion regulate dendritic cell epigenetic and transcription al landscapes to restrict dendritic cell maturation and tumour rejection. Cancer Immunol Res. 9:1354–69\n5. Savinko T\, Guenther C\, Uotila L\, Ll ort Asens M\, Yao S\, Tojkander S\, Fagerholm SC. 2018. Filamin A is requi red for optimal T cell integrin-mediated force transmission\, flow adhesio n and T cell trafficking. J Immunol. 200(9):3109-3116.\n6. Morrison VL\, J ames MJ\, Grzes K\, Cook P\, Glass DG\, Lek HS\, Gawden-Bone C\, Watts C\, Millington OR\, MacDonald AS\, Fagerholm SC. 2014. Loss of beta2-integrin -mediated cytoskeletal linkage reprograms dendritic cells to a mature migr atory phenotype. Nat Commun. 5: 5359. ATTACH;FMTTYPE=image/jpeg:https://bioscience.fi/wp-content/uploads/2025/09 /thumbnail-ImmunologySeminarSeriesFlyer-web_07102025.jpg CATEGORIES:Turku Bioscience Events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20250330T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR