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UID:1035@bioscience.fi
DTSTART;TZID=Europe/Helsinki;VALUE=DATE:20231103
DTEND;TZID=Europe/Helsinki;VALUE=DATE:20231104
DTSTAMP:20250304T083757Z
URL:https://bioscience.fi/events/ines-alvito-felix-from-rantakari-group-de
 fended-her-dissertation-in-medical-microbiology-and-immunology/
SUMMARY:Inês Alvito Félix from Rantakari group defended her dissertation 
 in Medical microbiology and immunology
DESCRIPTION:MSc Inês Alvito Félix defended her dissertation in Medical mi
 crobiology and immunology entitled “Ontogeny and function of adipose tis
 sue macrophages” at the University of Turku on 3 November 2023 at 12.00 
 (University of Turku\, Dentalia\, Arje Scheinin lecture hall\, Lemminkäis
 enkatu 2\, Turku).\n\nOpponent: Professor Francesc Villaroya (University o
 f Barcelona\, Spain)\nCustos: Docent Pia Rantakari (University of Turku)\n
 \nDoctoral Dissertation at UTUPub: https://urn.fi/URN:ISBN:978-951-29-9487
 -8\n\n***\n\nSummary of the Doctoral Dissertation:\n\nObesity is associate
 d with the accumulation of adipose tissue and increased risk of type II di
 abetes and cancer\, for example. This study explores the interaction betwe
 en macrophages of different origins and their function in maintaining ener
 gy balance and homeostasis of adipose tissue\, aiming to identify new targ
 ets for obesity prevention and treatment.\n\nMacrophages are immune cells 
 responsible for the clearance of pathogens and damaged cells\, being centr
 al to the inflammatory process. Beyond their immune functions\, they are c
 rucial for the healthy development and homeostasis of most tissues. Tissue
 -resident macrophages are specialized and perform tissue-specific function
 s. Each adult tissue hosts a unique pool of macrophages from different ori
 gins\, either from embryonic period (self-renewing within the tissue) or a
 fter birth from the bone marrow.\n\nAdipose tissue can be white\, the ener
 gy is stored as fat\, or brown the fat is converted into heat. I aimed to 
 understand the role of different origin macrophages in adipose tissue deve
 lopment and physiology by ing three murine fat depots: mammary gland (MG)\
 , epididymal white adipose tissue (WAT) and interscapular brown adipose ti
 ssue (BAT).\n\nAdipose tissue macrophages modulate the functioning of both
  healthy and diseased adipose tissues. They regulate MG development\, infl
 ux into the tissue and contribute to inflammation in WAT during obesity\, 
 and help maintain BAT‘s neuronal network. However\, whether the origin o
 f these macrophages has a significant impact on their functions within the
  tissue is still under study.\n\nMy research revealed that embryonic macro
 phages play a crucial role in the development of mammary ducts and remain 
 the primary macrophage population in adult MG. I present a novel unified a
 pproach for the subtyping of WAT macrophages and found that embryonic-deri
 ved macrophages maintain their numbers even in obesity\, suggesting a role
  in WAT homeostasis. In BAT\, my findings suggest that embryonic macrophag
 es are essential for neonatal thermogenesis but are rapidly replaced by bo
 ne marrow-derived macrophages during the first weeks of life.\n\nIn summar
 y\, embryonic-derived macrophages are vital for the healthy development of
  different adipose tissues\, each exhibiting specific functions and dynami
 cs depending on the fat pad they inhabit.
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