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UID:187044@bioscience.fi
DTSTART;TZID=Europe/Helsinki:20261111T150000
DTEND;TZID=Europe/Helsinki:20261111T160000
DTSTAMP:20261103T095812Z
URL:https://bioscience.fi/events/mist-guest-seminar/
SUMMARY:MIST Guest Seminar
DESCRIPTION:November 11th at 15:00-16:00\nLauren 2\, Medisiina D\n\nProf. M
 iguel Soares\, Gulbenkian Institute of Molecular Medicine (GIMM)\, Portuga
 l\n“Host defence adaptations to infection”\n\nHost: António Sousa (ag
 gode@utu.fi)\n\nCoffee and pulla served at 14:30\, first come first serve!
 \n\nBook a session with the guest: https://seafile.utu.fi/f/54c930db992d4b
 6c9e11\n\nMiguel Soares is a PI at the Gulbenkian Institute of Molecular M
 edicine (GIMM) in Portugal\, where he leads the Inflammation Laboratory (h
 ttps://gimm.pt/lab/miguel-soares-lab)\, and an invited professor at the Li
 sbon Medical School\, Universidade de Lisboa. He obtained his PhD from the
  University of Louvain in Belgium\, did his postdoctoral training at Harva
 rd Medical School in Boston\, and set up his lab at the Instituto Gulbenki
 an de Ciência in 2004. His lab studies how organisms survive infection. B
 esides fighting microbes directly (resistance)\, hosts can also limit the 
 damage an infection causes without reducing the pathogen load\, a strategy
  known as disease tolerance. The lab investigates how stress responses and
  inter-organ communication rewire host metabolism to make this possible\, 
 mainly in malaria and sepsis. Its contributions include uncovering the pro
 tective roles of carbon monoxide and sickle haemoglobin in malaria\, and s
 howing that cross-regulation of iron and glucose metabolism establishes di
 sease tolerance to sepsis. Most recently\, the lab has shown that jaundice
  may be a shield rather than a symptom: bilirubin accumulation during mala
 ria appears to be an adaptive response that helps kill the parasite and pr
 otect host tissues. This work is now funded by his second ERC Advanced Gra
 nt (KILLBILL)\, which will explore bilirubin as a weapon against the paras
 ite\, a shield for host tissues and a modulator of immune responses. It is
  also funded by the “la Caixa” Foundation to investigate whether bilir
 ubin protects the kidneys of children with severe malaria and to identify 
 early biomarkers of acute kidney injury.\n\nSelected publications:\n\nPamp
 lona A\, Ferreira A\, Balla J\, Jeney V\, Balla G\, Epiphanio S\, Chora A\
 , Rodrigues CD\, Gregoire IP\, Cunha-Rodrigues M\, Portugal S\, Soares MP\
 , Mota MM. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis 
 of experimental cerebral malaria. Nat Med. 2007 Jun\;13(6):703-710.\n\nFer
 reira A\, Marguti I\, Bechmann I\, Jeney V\, Chora A\, Palha NR\, Rebelo S
 \, Henri A\, Beuzard Y\, Soares MP. Sickle hemoglobin confers tolerance to
  Plasmodium infection. Cell. 2011 Apr 29\;145(3):398-409.\n\nMedzhitov R\,
  Schneider DS\, Soares MP. Disease tolerance as a defense strategy. Scienc
 e. 2012 Feb 24\;335(6071):936-941.\n\nWeis S\, Carlos AR\, Moita MR\, Sing
 h S\, Blankenhaus B\, Cardoso S\, Larsen R\, Rebelo S\, Schäuble S\, Del 
 Barrio L\, Mithieux G\, Rajas F\, Lindig S\, Bauer M\, Soares MP. Metaboli
 c adaptation establishes disease tolerance to sepsis. Cell. 2017 Jun 15\;1
 69(7):1263-1275.e14.\n\nFigueiredo A\, Rastogi ST\, …\, Portugal S\, Kur
 th F\, Elo LL\, Paul BD\, Martins R\, Soares MP. A metabolite-based resist
 ance mechanism against malaria. Science. 2025 Jun 12\;388(6752):eadq6741.
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CATEGORIES:Turku Bioscience Events
LOCATION:Lauren 2 (MED D1016)\, Kiinamyllynkatu 10\, Turku\, 20520\, Finlan
 d
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Kiinamyllynkatu 10\, Turku\
 , 20520\, Finland;X-APPLE-RADIUS=100;X-TITLE=Lauren 2 (MED D1016):geo:0,0
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