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UID:1040@bioscience.fi
DTSTART;TZID=Europe/Helsinki;VALUE=DATE:20230928
DTEND;TZID=Europe/Helsinki;VALUE=DATE:20230929
DTSTAMP:20250304T083757Z
URL:https://bioscience.fi/events/ye-hong-from-laura-elos-and-eleanor-coffe
 ys-groups-defended-her-thesis-in-bioinformatics/
SUMMARY:Ye Hong from Laura Elo's and Eleanor Coffey's groups defended her t
 hesis in Bioinformatics
DESCRIPTION:On 28 September Ye Hong from Laura Elo's and Eleanor Coffey's g
 roups defended her thesis in Bioinformatics titled "Evaluation of the rele
 vance and impact of kinase dysfunction in neurological disorders through p
 roteomics and phosphoproteomics bioinformatics analysis”. Ye's opponent 
 was Prof. Jacques Colinge from University of Montpellier\, France.\n\nCong
 ratulations Ye!\n\nAbstract:\n\nThis dissertation explores the world of pr
 otein phosphorylation\, a critical post-translational modification that pl
 ays a key role in cellular functions. The focus is on the neurological dis
 orders of schizophrenia and Parkinsons disease\, specifically investigatin
 g the phosphoproteome and protein abundance.\n\nStudy I introduces PhosPiR
 \, an automated analysis pipeline in R\, aimed at streamlining the proteom
 ics and phosphoproteomics data processing. This tool can perform a multi-l
 evel functional analysis of MS data and supports 18 different organisms. I
 t offers a comprehensive approach to MS data analysis\, including preproce
 ssing\, normalization\, enrichment analysis\, network analysis\, and more.
 \n\nStudy II investigates the LRRK2-G2019S mutations function in the brain
 \, specifically its localization to the small 40S ribosomal subunit and su
 ppression of RNA translation. The findings were validated using different 
 models\, including Parkinsons disease patient cells.\n\nStudy III uses bio
 -orthogonal non-canonical amino acid tagging to identify nascent proteins 
 affected by repressed translation. The analysis reveals significant change
 s in specific biological processes\, which were further validated through 
 targeted proteomics and immunoblotting.\n\nStudy IV focuses on the role of
  JNK1 in schizophrenia. Using wild type and Jnk1-/- mice\, LC-MS/MS analys
 is identifies 126 schizophrenia-associated proteins that overlap with sign
 ificantly differentially phosphorylated proteins in the Jnk1-/- mice brain
 . The study highlights the NMDAR trafficking pathway and shows a decrease 
 in surface expression of NMDAR subunits in Jnk1-/- neurons. Behavioral tes
 ts further link the Jnk1-/- molecular and behavioral phenotype with schizo
 phrenia and neuropsychiatric disease.\n\nThe insights into the LRRK2-G2019
 S mutations role in Parkinsons and the phosphorylation profiles connection
  to schizophrenia pave the way for potential new therapeutic interventions
 .\n\nDownload full dissertation.
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