Publications

    Peer-reviewed scientific articles

    * Equal contribution/corresponding author
    1. Driessen RCH, Stassen OMJA, Sjöqvist M, Suarez Rodriguez F, Grolleman J, Bouten CVC, Sahlgren CM.Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Integr Biol (Camb). 2018 Nov 12;10(11):719-726. doi: 10.1039/c8ib00036k.
    2. William Fausto Quiros-Solano, Nikolas Gaio, Oscar Stassen, Yusuf Arik, Cinzia Silvestri, Nicole Van Engeland, Andries Van der Meer, Robert Passier, Cecilia Sahlgren, Carlijn Bouten, Albert van den Berg, Ronald Dekker, and Pasqualina Sarro. Microfabricated tuneable and transferable porous PDMS membranes for Organ-on-Chips. Sci Rep.
    3. Valeriy M Paramonov, Diti Desai, Helene Kettiger, Veronika Mamaeva, Jessica M. Rosenholm, Cecilia Sahlgren and Adolfo Rivero-Müller. Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles – Are We Striking Home. Nanotheranostics doi:10.7150/ntno.23826
    4. Anders P. Mutvei, Sebastian K.-J. Landor, Rhys Fox, Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Cecilia Sahlgren, Johan Hartman, Jonas Bergh, Shaobo Jin and Urban Lendahl (2018) Notch signaling promotes a HIF2alpha driven hypoxic response in multiple tumor cell types. Oncogene doi: 10.1038/s41388-018-0400-3
    5. Nicole C.A. van Engeland, Andreas M.A.O. Pollet, Carlijn V.C. Bouten, Oscar M.J.A. Stassen, Cecilia M. Sahlgren. (2018) A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions Lab on a Chip doi: 10.1039/c8lc00286
    6. L. A. Tiemeijer, J-P. M. S. Frimat, O. M. J. A. Stassen, C. V. C. Bouten, and C. M. Sahlgren. (2018) Spatial patterning of the Notch ligand Dll4 to control endothelial sprouting in vitro. Scientific Reports doi: 10.1038/s41598-018-24646-y
    7. Sandra Loerakker, Oscar M.J.A. Stassen, Fleur ter Huurne, Marcelo Boareto, Carlijn V.C. Bouten, Cecilia M. Sahlgren.  (2018) Mechanosensitivity of Jagged–Notch signalling can induce a switch-type behavior in vascular homeostasis. PNAS doi: 10.1073/pnas.1715277115
    8. Jelle Sleeboom, Hossein Eslami Amirabad, Poornima Karmachandran Nair, Cecilia Sahlgren, Jaap van den Toonder. (2018) Putting metastasis in context: modelling the tumour microenvironment with cancer-on-chip approaches. Disease models and mechanisms DMM/2017/033100. doi: 10.1242/dmm.033100.
    9. Nobuyuki Tanaka, Dagmara Kaczynska, Shigeaki Kanatani, CeciliaSahlgren, Przemysław Mitura, Andrzej Stepulak, Ayako Miyakawa, Peter Wiklund, and Per Uhlén. (2018) Mapping of the Three-Dimensional Lymphatic Microvasculature in Bladder Tumours Using Light-Sheet Microscopy British Journal of Cancer MD-2017-3442R doi: 10.1038/s41416-018-0016-y
    10. Christian J.M. Antila, Vilma Rraklli, Henri A. Blomster, Käthe M. Dahlström, Tiina A. Salminen, Johan Holmberg, Lea Sistonen, CeciliaSahlgren. (2018) Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death and Differentiation CDD-17-0032 doi: 10.1038/s41418-017-0002-6
    11. Tan Nobuyuki Tanaka, Shigeaki Kanatani, Raju Tomer, CeciliaSahlgren, Pauliina Kronqvist, Dagmara Kaczynska, Lauri Louhivuori, Lorand Kis, Claes Lindh, Przemysław Mitura, Andrzej Stepulak, Sara Corvigno, Johan Hartman, Patrick Micke, Artur Mezheyeuski, Carina Strell, Joseph W. Carlson, Carlos Fernández Moro, Hanna Dahlstrand, Arne Östman, Kazuhiro Matsumoto, Peter Wiklund, Mototsugu Oya, Ayako Miyakawa, Karl Deisseroth, and Per Uhlén. (2018) Whole-tissue biopsy phenotyping of three-dimensional tumours reveals cancer heterogeneity. Nature Biomedical Engineering doi:10.1038/s41551-017-0139-0.
    12. Arianna Mauretti, Fabrizio Rossi, Noortje A.M. Bax, Carmen Miano, Fabio Miraldi, Marie José Goumans, Elisa Messina, Alessandro Giacomello, Carlijn V.C. Bouten, Cecilia Sahlgren. (2018) Spheroid 3D culture and hypoxia activate Notch signaling in cardiac progenitor cells MRS Communication, doi: 10.1557/mrc.2017.82
    13. Arianna Mauretti, Sergio Spaans, Noortje A.M. Bax, Cecilia Sahlgren, Carlijn V.C. Bouten. (2017) Cardiac progenitor cells and the interplay with their microenvironment Stem Cells International, doi: 10.1155/2017/7471582
    14. Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Didem Şen Karaman, Outi M.H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm, Niklas Sandler. (2017) Tailored approaches in drug development and diagnostics – from molecular design to biological model systems. Advanced Health Care Materials Manuscript doi: 10.1002/adhm.201700258.
    15. Ilkka Paatero, Eudald Casals, Rasmus Niemi, Ezgi Özliseli, Jessica M. Rosenholm and Cecilia Sahlgren. (2017) Analyses in zebrafish embryos reveal surface functionalization- and tissue penetrance-dependent toxicity of mesoporous silica nanoparticles. Scientific Reports, 7:8423. doi: 10.1038/s41598-017-09312-z
    16. Daniel Antfolk, Marika Sjoqvist, Fang Cheng, Kimmo Isonniemi, Camille L. Duran, Adolfo Rivero-Muller, Christian Antila , Rasmus Niemi , Sebastian Landor, Carlijn C.V. Bouten, Kayla J. Bayless, John E. Eriksson, Cecilia Maria Sahlgren. (2017) Selective regulation of Notch ligands during angiogenesis is mediated by vimentin PNAS doi: 10.1073/pnas.1703057114.
    17. Lahdeniem IAK, Antila CA, Misiorek JO, Fortelius LE, Nyström, JH, Sahlgren C* & Toivola DM*. (2017) Keratins regulate colonic epithelial cell differentiation through the Notch1 signaling pathway. Cell Death and Differentiation doi: 10.1038/cdd.2017.2
    18. Mauretti A, Bax NAM, Goumans MJ, Sahlgren C & Bouten CVC. (2016) The mechanosome develops upon differentiation in cardiomyocyte progenitor cells. Integrative Biology 8:991-1001 doi: 10.1039/C6IB00117C
    19. Baghirov H, Karaman D, Viitala T, Duchanoy A,  Lou Y-R, Mameva V, Pryazhnikov E, Leonard Khiroug L, de Lange Davies C, Sahlgren C* & Rosenholm J*. (2016) Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier PLoS One in press doi: 10.1371/journal.pone.0160705
    20. Santio N, Landor S, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi S, Corthals G, Varjosalo M, Manoharan G, Uri A, Lendahl U, Sahlgren C* & Koskinen P*. (2016) Pim kinases regulate oncogenic Notch1 signaling. Oncotarget. doi: 10.18632/oncotarget.9215.
    21. Braune E-B, Tsoi YL, Phoon YP, Landor S, Cascales HS, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren C, Jin S-B & Lendahl U (2016) Loss of CSL unlocks a hypoxic response and enhanced tumor growth potential in breast cancer cells. Stem Cell Reports doi: 10.1016/j.stemcr.2016.03.00
    22. Mamaeva V, Niemi R, Beck M, Özliseli E, Desai D, Landor S, Gronroos T, Kronqvist P, McCormack E, Rosenholm JM, Linden M & Sahlgren C (2016) Inhibiting Notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying gamma-secretase inhibitors. Molecular Therapy doi: 10.1038/mt.2016.42
    23. Rosenholm JM, Zhang J, Lindén M & Sahlgren C (2016) Mesoporous silica nanoparticles in tissue engineering – a perspective. Nanomedicine 11:391-402
    24. Rosenholm JM, Gulin-Sarfraz T, Mamaeva V, Niemi R, Özliseli E, Desai D, Antfolk D, von Haartman E, Lindberg D, Prabhakar N, Näreoja T & Sahlgren C (2016) Prolonged dye release from mesoporous silica-based imaging probes facilitates long-term optical tracking of cell populations in vivo. Small doi: 10.1002/smll.201503392
    25. Desai D, Prabhakar N, Mamaeva V, Șen Karaman D, Lähdeniemi IAK, Rajput SJ, Sahlgren C*, Rosenholm JM* & Toivola DM* (2016) Targeted Modulation of Cell Differentiation in Distinct Regions of the Gastrointestinal Tract via Oral Administration of Differently PEI-PEG Functionalized Mesoporous Silica Nanoparticles. International Journal of Nanomedicine doi: 10.2147/IJN.S94013.
    26. Chivukula IV, Ramsköl D, Storvall H, Anderberg C, Jin S, Mamaeva V, Sahlgren C, Pietras K, Sandberg R, Lendahl U (2015) Decoding breast cancer tissue-stroma interactions using species-specific sequencing. Breast Cancer doi: 10.1186/s13058-015-0616-x
    27. Paramonov V, Mamaeva V, Sahlgren C & Rivero-Müller A (2015) Genetically-encoded tools for cAMP probing and modulation in living systems. Frontiers in pharmacology 6, doi: 10.3389/fphar.2015.00196.
    28. Shokry H, Vanamo U, Wiltschka O, Niinimäki J, Lerche M, Levon K, Linden M & Sahlgren C (2015) Mesoporous silica particle-PLG-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization. Nanoscale 7:14434-43