Email: daniel.abankwa [at] utu.fi
Email: daniel.abankwa [at] uni.lu
Phone: (+352) 46 66 44 6897
Description of the Research
The number of cancer caused deaths in the world is expected to rise from about 9M in 2015 to 15M in the following 20 years. Novel therapeutic approaches against cancer are therefore urgently needed.
We are developing novel targeted drugs, which would be administered in a personalized manner, depending on gene expression, mutation status and/or other diagnostic parameters (altogether biomarkers) obtained from the patient.
We focus on specifically inhibiting the aberrant activity of one of the cancer associated Ras isoforms encoded by HRAS, NRAS or KRAS genes.
Additional information on our activities can be found here.
Our Research Aims in Turku are:
- Drug Development– to develop novel drugs that block RAS-dependent stemness signaling in cancer.
- Target Nomination– to understand which components of RAS interaction network in particular in membrane signaling hubs (nanocluster) could be targeted with novel drugs
- Molecular cell biology (2D proliferation, 3D sphere cultures, inducible lentiviral vectors, knock-down and out etc.)
- Biochemistry (assay development, protein interaction, structure etc.)
- Quantitative fluorescence methods and confocal imaging (FRET, FRAP etc.)
The role of the Galectin-1/ Raf interface in promoting cancer cell stemness
Funded by the Jane and Aatos Erkko Foundation
Academy of Finland
Sigrid Juselius foundation
Jane and Aatos Erkko foundation