Selected publications

Miikkulainen P, Högel H, Rantanen K, Suomi T, Kouvonen P, Elo LL, Jaakkola PM. (2017). HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma. Cancer Metab. Jul 4;5:5.

Seyednasrollah F, Rantanen K, Jaakkola P, Elo LL. (2016). ROTS: reproducible RNA-seq biomarker detector-prognostic markers for clear cell renal cell cancer. Nucleic Acids Res. Jan 8;44(1):e1.

Högel H, Miikkulainen P, Bino L, Jaakkola PM. (2015). Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. Jul 30;14:143.

Silén J, Högel H, Kivinen K, Silvoniemi A, Forsback S, Löyttyniemi E, Solin O, Grénman R, Minn H, Jaakkola PM, Grönroos TJ. (2014). Uptake of [¹⁸F]EF5 as a Tracer for Hypoxic and Aggressive Phenotype in Experimental Head and Neck Squamous Cell Carcinoma. Transl Oncol. May 23. pii: S1936-5233(14)00047-3.

Rantanen K., Pursiheimo J., Högel H., Miikkulainen P., Sundström J. and, Jaakkola P.M. (2013). p62/SQSTM1 regulates hypoxia response by attenuating normoxic PHD3 activity through aggregate sequestration and enhanced degradation. J Cell Sci. Mar 1;126(Pt 5):1144-54.

Rantanen K., Pursiheimo J., Högel H., Miikkulainen P., Sundström J. and, Jaakkola P.M. (2012). p62/SQSTM1 regulates hypoxia response by attenuating normoxic PHD3 activity through aggregate sequestration and enhanced degradation. J Cell Sci. Jan 23.

Högel H., Rantanen K., Jokilehto T., Grenman R. and, Jaakkola P.M. (2011). Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PloS One 6(11):e27112

Heikkinen P., Nummela M., Kähäri V.M. and Jaakkola  P.M. (2010). Hypoxia converts Smad7 from tumor suppressor into tumor promoter. Cancer Res., 70(14):5984-93.

Heikkinen P.T., Nummela M., Leivonen S.K., Westermarck J., Hill C.S., Kähäri V.-M., Jaakkola P.M. (2010). Hypoxia activated Smad3-specific dephosphorylation by PP2A. (2010).  J Biol.Chem., 285(6):3740-9.

Jokilehto T., Högel H., Heikkinen, P., Rantanen K., Elenius, K., Sundström J., Jaakkola P.M. (2010). Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Exp. Cell Res.  316(7):1169-78.

Pursiheimo J., Rantanen K., Heikkinen P.T., Johansen T., Jaakkola P.M. (2009). Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62. Oncogene, 28(3):334-344.

Luukkaa M., Jokilehto T, Kronqvist P., Vahlberg, T., Grénman, R., Jaakkola P. and Minn, H. (2009). Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensivity in squamous cell cancer of the head and neck. Int J Radiat Biol. Jul 9:1-9.

Rantanen K., Pursiheimo J., Högel H., Himanen V., Metzen E., Jaakkola P.M. (2008) Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation. Mol Biol Cell 19(5):2231-40.

Jokilehto, T., Rantanen, K., Luukkaa, M., Heikkinen, P., Grenman, R., Minn, H., Kronqvist, P., Jaakkola P.M. (2006). Overexpression and nuclear translocation of HIF prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma associates with tumor aggressiveness. Clin Cancer Res 12(4):1080-1087.

Epstein, A.C.R., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O’Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A., Tian, Y.-M., Masson, N., Hamilton, D.L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P.H., Pugh, C.W., Schofield, C.J., Ratcliffe, P.J. (2001). C.elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF through prolyl hydroxylation. Cell 107; 43-54.

Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M.I., Gielbert, J., Gaskell, S.J., Kriegsheim, Av, Hebestreit, H.F., Mukherji, M., Schofield, C.J., Maxwell, P.H., Pugh, C.W., Ratcliffe, P.J. (2001). Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292; 468-72.

Reviews
Jaakkola P.M., Rantanen K. (2013) The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3. Biol Chem. Apr;394(4).

Jokilehto T., Jaakkola P.M. (2010) The role of HIF prolyl hydroxylases in tumor growth. J Cell Mol Med. 14(4):758-70.

Jaakkola P.M., Pursiheimo JP. (2009) p62 degradation by autophagy: Another way for cancer cells to survive under hypoxia.  Autophagy. Apr 16;5(3).