Turku Bioscience – Turku Centre for Biotechnology

1900 Researchers from Turku Bioscience Centre Identified Novel Oncogenic Function for Receptor Linked with Alzheimer’s Disease
1900 Business Finland TUTLI grant awarded to Coffey lab to develop Parkinson’s Disease diagnostic test towards commercialization.
1900 Turku Bioscience staff trip to Rosala Viking Village
1900 Johanna Ivaska receives funding from Academy of Finland
1900 Turku Bioscience team gets broad attention at Live Science Live
1900 Two Academy Research Fellows selected from Turku Bioscience

Recent publications

Chronopoulou, E.G. et al. Structure-based design and application of an engineered glutathione transferase for the development of an optical biosensor for pesticides determination Biochim Biophys Acta. 2019;1863:565-576 Pubmed→

Theoharaki, C. et al. Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora. Funct. Integr. Genomics. 2019;19:1-12 Pubmed→

Wang L et al. Conductive carbon microfibers derived from wet-spun lignin/nanocellulose hydrogels. ACS Sustain Chem Eng 7 (6). 2019; 6013-6022 Pubmed→

Manoharan GB et al. High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors. Anal Biochem. 2019 Feb 27. Pubmed→

Buehler U et al. Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity. EMBO J. 2018 Aug 15;37(16). Pubmed→

Sahlgren C et al. Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Adv Healthc Mater. 2017 Nov;6(21). Pubmed→

Tripathi SK et al. Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization. iScience. 2018 Dec 26;11:334-355. Pubmed→

Henriksson J et al. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Cell. 2019 Jan 7, 2019. Pubmed→

Moreno-Layseca P et al. Integrin trafficking in cells and tissues.Nat Cell Biol. 2019 Jan 2. [Epub ahead of print] Review Pubmed→

Jacquemet G et al. (2019). Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability. Curr Biol 29, 1–15. Link to text→

Lee WH et al. ZLc002, a putative small molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. Mol Pain. Aug 29:1744806918801224.Pubmed→

Robinson S and Courtney MJ. Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields. Bioinformatics, Sep 15;34(18):3196-3204.Pubmed→

Tripathi SK et al. Quantitative mass spectrometry-based proteomics reveals the dynamic protein landscape during initiation of human Th17 cell polarization. iScience, in press, 2019. Link to text→

Shentu YP et al. CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.Pubmed→

Johannessen TA et al. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 2018 Oct 5. Pubmed→

Rytkönen KT et al. Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs. Reproductive Sciences. 2018 Oct 11:1933719118802056. Pubmed→

Minghua Yao et al. Theranostic Role of Cobalt Protoporphyrin Nano-Formulation for Photoacoustic Imaging Guided Stem Cell Implantation. Accepted

Wei Li et al. Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine. Biomaterials. 2018 Sep 19;185:322-332. Pubmed →

Xingzhi Liu et al. Immunological Electrospun Scaffold for Tumor Imprison Killing and Healthy Tissue Regeneration. Mater. Horiz. 2018. Link→

Xiaoming Sun et al. Adjustable hardness of hydrogel for promoting vascularization and maintaining stemness of stem cells in skin flap regeneration. Science Direct. 2018 Dec;13;54-63. Link→

Xia Guanggai et al. Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence. Advanced Healthcare Materials. 2018 Sep;7(18):e1800593.Pubmed →

Jianfeng Ji et al. Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer. Advanced Functional Materials. 2018 Aug; 28(33):1801738.

Feng Zhang et al. Sequential Antifouling Surface for Efficient Modulation of the Nanoparticle-Cell Interactions in Protein-Rich Environment. 2018. Link →

Rubio Zhong et al. Self‐Assembly of Enzyme‐Like Nanofibrous G‐Molecular Hydrogel for Printed Flexible Electrochemical Sensors. Advanced Materials. 2018 Mar;30(12):e1706887. Pubmed→

Yueqi Zhu et al. Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials. 2018 Sept. 28.

Mathieu C et al.Immunological biomarkers for the development and progression of type 1 diabetes. Diabetologia. 2018 Sep 12. Pubmed→

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