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Turku Bioscience Centre

Turku Bioscience Centre

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State-of-the-art technology and research

State-of-the-art technology and research

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Biological and biomedical research

Biological and biomedical research

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Recent publications

Nagelli S et al. CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response. Trends in Cancer. 2023 Oct 2. Link →
Oras A et al. Profiling of peripheral blood B-cell transcriptome in children who developed coeliac disease in a prospective study. Heliyon. 2023 Jan 21;9(2):e13147. Pubmed →
Brunell A E et al. Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities. Frontiers in Immunology. 2023 Apr 14;14:1151632.Pubmed →
Suomi T et al. Gene expression signature predicts rate of type 1 diabetes progression. EBioMedicine. 2023 Jun;92:104625. Pubmed →
Moulder R et al. Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory. Diabetologia. 2023 Nov;66(11):1983-1996. Pubmed →
Lamichhane S et al. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Frontiers in Endocrinology. 2023 Sep 6;14:1211015. Pubmed →
Hirvonen M K et al. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Scientific Reports. 2023 Sep 24;13(1):15941. Pubmed →
Cazzoli R et al. Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition. Cell Reports. 2023 Jun 7;42(6):112616. Online ahead of print. Pubmed →
Örd T et al. Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures. American Journal of Human Genetics. 2023.Apr 11;S0002-9297(23)00097-6. Pubmed →
Westermarck J. Inhibition of adaptive therapy tolerance in cancer: is triplet mitochondrial targeting the key?. Molecular Oncology. 2023. Feb 28. Pubmed →
Huuhtanen J. et al. Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients. Journal of Clinical Investigation. 2023. Jan 31;e164809. Pubmed →
Aakula A et al. RAS and PP2A activities converge on epigenetic gene regulation. Life Science Alliance. 2023 Mar 1;6(5):e202301928. Pubmed →
Pavic K et al. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature Communications. 2023 Feb 28;14(1):1143. Pubmed →
Vaparanta K et al. An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation. Nature Communications. 2022. Nov 14;13(1):6953. Pubmed →
Aakula A et al. PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers. Molecular Oncology. 2022. Dec 3. Online ahead of print. Pubmed →
de Thonel A et al. CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nature Communications. 2022. Nov 16: 13;7002. Link to Page→
Hu WT et al. CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization. EMBO reports. 2022. Oct 28; e54911. Link to Page→
Peuhu E et al. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. Developmental Cell. 2022. Oct 24: 57;20. Link to Page→
Butt U et al. SHARPIN serine 146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion, and metastasis. Journal of Cell Science. 2022. Sep 23;jcs.260627. Online ahead of print. Pubmed→
Rytkönen KT et al. Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia. Reproduction. 2022. Sep 1;REP-22-0079. Pubmed→
Mohd Moin Khan et al. Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation. Frontiers in Immunology. 2022. Jun 15;13:856762. Pubmed→

Virtual tour of our services

News

  • 1897 news-image Ye Hong from Laura Elo’s and Eleanor Coffey’s groups defended her thesis in Bioinformatics
  • 1897 news-image Immunology Seminar Series: Vivianne Malmström
  • 1897 news-image The Finnish Research Impact Foundation awarded Professor Riitta Lahesmaa €224,639 in funding
  • 1897 news-image Frontiers of Science autumn seminars staring on Thursday 28 September

Events

  • 1901 news-image Immunology Seminar Series: Vivianne Malmström
  • 1901 news-image Doctoral Defence Nigatu Adossa
  • 1901 news-image Frontiers of Science: Prof. Alpha Yap
  • 1901 news-image Frontiers of Science: Prof. Francesc Villarroya
  •  All news and events →

    Upcoming events

      Immunology Seminar Series: Vivianne Malmström
      10.10.2023

      Doctoral Defence Nigatu Adossa
      13.10.2023

      Frontiers of Science: Prof. Alpha Yap
      26.10.2023

      Frontiers of Science: Prof. Francesc Villarroya
      2.11.2023

      Frontiers of Science: Academician of Science Merja Penttilä
      9.11.2023

     Events calendar→
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