Dissertation Defence: MSc Nirman Poudel

    Glutathione transferases are important enzymes that play a key role in protecting cells from various threats, including foreign chemicals (xenobiotics). In MSc Nirmal Poudel’s thesis, the crystal structures of four glutathione transferases from different plants and mammals were determined using the technique of X-ray crystallography. The structures revealed in detail the position of important residues involved in the binding and inactivation of xenobiotics. They also revealed changes in the structures during the binding of xenobiotics. The information reported in this thesis will be useful in designing new molecules as enzyme inhibitors to block the activity of glutathione transferases involved in drug and herbicide resistance.

    MSc Nirman Poudel will present his thesis on Friday, October 21.

    Opponent: Prof. Dr Arwen Pearson (University of Hamburg, Germany)

    Custos: Prof. Jyrki Heino (University of Turku, Finland)

    Time: Friday, October 21at , 12.15-3.15PM

    Place: Pha1 auditorium, Pharmacity, Itäinen Pitkäkatu 4

    You can download and read Poudel’s thesis in advance:  https://urn.fi/URN:ISBN:978-951-29-8964-5