Frontiers of Science: Jacco van Rheenen
November 4th at 12:00
Prof. Jacco van Rheenen, Netherlands Cancer Institute, The Netherlands
Intravital microscopy reveals mechanisms of tumor induction
host: Emilia Peuhu (firstname.lastname@example.org)
Register latest on November 3rd at 12:00
Students and early-career postdocs are welcome to share a virtual cup of coffee and discuss with Prof. Jacco van Rheenan after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for future. Every student are welcome to join, in spite of which research group they belong to.
If you got interested, after registering to the event please send an email to email@example.com
Jacco van Rheenen was originally trained in a variety of imaging techniques during his PhD with Dr. Kees Jalink at the Netherlands Cancer Institute. He was among the first to optimize imaging and develop software to quantitatively measure FRET on confocal microscopes. During his PhD in the lab of Dr. Jalink and as postdoc in the lab of Dr. Sonnenberg (Netherlands Cancer Institute) he used several microscopy techniques to study lipid signaling in tumor cells. In order to broader his scales, he obtained a KWF fellowship to do a postdoc in the United States in the lab of Dr. John Condeelis at the Albert Einstein College of Medicine. There he extended his imaging experience by imaging mammary tumors intravitally including two-photon microscopy and became an expert in the field of intravital FRET imaging. In 2008 he was appointed as group leader at the Hubrecht Institute, where he utilizes his imaging techniques to visualize processes that are required for the metastasis of tumor cells in living animals. In July 2014 he was appointed professor in Intravital Microscopy at the University Medical Center Utrecht. In October 2017 he became senior group leader at the Netherlands Cancer Institute (NKI) and the Oncode Institute. In 2009, he was awarded a VIDI award from Netherlands Organization for Scientific Research. In 2013, he received the Stem Cells Young Investigator Award. In 2015, he was awarded an ERC consolidator grant, in 2017 the Dr. Josef Steiner Cancer Research Foundation Award, and in 2019 the Ammodo Science Award
Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J. Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer. Cell Stem Cell. 2020 Apr 2;26(4):569-578.e7. doi: 10.1016/j.stem.2020.02.008. Epub 2020 Mar 12.
Bruens L, Ellenbroek SIJ, Suijkerbuijk SJE, Azkanaz M, Hale AJ, Toonen P, Flanagan DJ, Sansom OJ, Snippert HJ, van Rheenen J.
Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine. Cell Rep. 2020 Jul 21;32(3):107937. doi: 10.1016/j.celrep.2020.107937.
Bornes L, van Scheppingen RH, Beerling E, Schelfhorst T, Ellenbroek SIJ, Seinstra D, van Rheenen J. Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT (2019) Cell Rep. Nov 26;29(9):2565-2569.e3. doi: 10.1016/j.celrep.2019.10.107.
Scheele CL, Hannezo E, Muraro MJ, Zomer A, Langedijk NS, van Oudenaarden A, Simons BD, van Rheenen J. Identity and dynamics of mammary stem cells during branching morphogenesis (2017) Nature. Feb 16;542(7641):313-317. doi: 10.1038/nature21046. Epub 2017 Jan 30.
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