Frontiers of Science: Prof. Michael O. Hottiger
May 23rd at 12:00
Presidentti auditorium, BioCity
Spring 2024 program
Prof. Michael O. Hottiger, University of Zurich, Switzerland
Uncovering ADP-ribosylation signaling pathways: implications for PARP7 in cancer
Host: Lea Sistonen (firstname.lastname@example.org)
Coffee and sandwich at 11:45, first come first served!
Six PhD researchers and early-career postdocs are welcome to have a lunch in restaurant Mauno and discuss with Prof. Hottiger after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.
If you got interested, please send an email to email@example.com
Hottiger lab investigates inflammatory signaling (e.g. oxidative stress) with special focus on the role of post-translations modifications (PTM) such as ADP-ribosylation in the regulation of inflammation. PTMs of proteins are thought to contribute to the observed complexity of cellular processes in animal and man. PTMs may help to explain the differences between e.g. worm and man, considering that the number and the nucleotide sequences of genes is rather comparable among animal species. Hottiger lab studies the patterns of ADP-ribosylation using cutting-edge systems biology approaches such as ADP-ribosyl-specific high-resolution and quantitative mass spectrometry that are developed in house or in collaboration with various colleagues worldwide. Furthermore, Hottiger lab investigates the players involved, such as writers, readers and eraser of ADP-ribosylation, as well as their target proteins that carry this PTM using state-of-the-art proteomics methods.
Muskalla L, Güldenpfennig A, Hottiger MO. Subcellular Quantitation of ADP-Ribosylation by High-Content Microscopy. 2023. Methods Mol Biol. 2023;2609:101-109. doi: 10.1007/978-1-0716-2891-1_7
Schraml P, Aimi F, Zoche M, Aguilera-Garcia D, Arnold F, Moch H, Hottiger MO. 2023. Altered cytoplasmic and nuclear ADP-ribosylation levels analyzed with an improved ADP-ribose binder are a prognostic factor in renal cell carcinoma. J Pathol Clin Res. 2023 Mar 31. doi: 10.1002/cjp2.320
Liu L, Sandow JJ, Leslie Pedrioli DM, Samson AL, Silke N, Kratina T, Ambrose RL, Doerflinger M, Hu Z, Morrish E, Chau D, Kueh AJ, Fitzibbon C, Pellegrini M, Pearson JS, Hottiger MO, Webb AI, Lalaoui N, Silke J. 2022. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death. Sci Adv. 2022 May 13;8(19):eabh2332. doi: 10.1126/sciadv.abh2332
- You can download and save all the spring 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
- Registration is not needed, participation list is circulated in the audience
- If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
- Please note that any audio or video recording of the seminars is strictly forbidden.
- Spring 2024 FoS image credits to Jenny Pessa: Transformed human breast epithelial HS578T cells (flattened), labelled with commercial fluorescent antibodies. Image acquired on 3i CSU-W1 Spinning disk with 40x objective.