Immunology Seminar

September 6^th at 14:00 – 15:00
Virtual event

Doreen Cantrell, University of Dundee, UK: “Fuelling T cells”

Host: Riitta Lahesmaa (rilahes@utu.fi )

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

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Doreen Cantrell studied Zoology at The University College of Wales in Aberystwyth and then did a PhD in Cellular Immunology at the University of Nottingham. She made the move to do a postdoctoral fellowship at Dartmouth Medical School in New Hampshire to work with Kendall Smith on the control of T cell growth and proliferation. A second postdoctoral fellowship with Michael Crumpton at the Imperial Cancer Research Fund Laboratories (ICRF) in London launched her interest in biochemistry/signal transduction and provided the impetus for the establishment of the Lymphocyte Activation Laboratory within the ICRF. After 15 years as a Principal Investigator in ICRF, the award of a Wellcome Trust Principal Research Fellowship in 2002 provided the mechanism to move Doreen’s group to the University of Dundee. As world leading Centre for Life Sciences research provides perfect environment for Doreen’s program to study how serine/threonine kinases control T cell immune responses. Doreen continues to work on signal transduction pathways in T lymphocytes.

Selected publications:

Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell D.A. Antigen receptor control of methionine metabolism in T cells. eLife. Mar 27;8, 2019.

Howden AJM, Hukelmann JL, Brenes A, Spinelli L, Sinclair LV, Lamond AI, Cantrell DA. Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation.  Nature Immunology 20: 1542-1554, 2019.

Marchingo JM, Sinclair LV, Howden AJ, Cantrell DA. Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation.  eLife. Feb 5;9, 2020.