Profile

    Group Leader

    Matej Orešič, Ph.D., Adjunct Professor
    matej.oresic [at] utu.fi

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    Curriculum Vitae
    Publications

    Contact Information

    Turku Bioscience
    P.O. Box 123, BioCity
    (Street addr. Tykistökatu 6 B)
    FIN-20521 Turku, Finland
    Phone: +358 44 972 6094
    Email: matej.oresic [at] utu.fi


    Description of the Research

    Systems medicine combines both systems biology and computational modelling to bring together physiological, genetic, environmental, molecular and biochemical interactions to advance the field of medicine. We focus on metabolomics applications in biomedical research and related integrative bioinformatics. We are particularly interested in the identification of vulnerabilities to disease associated with metabolic phenotypes and the underlying mechanisms linking these vulnerabilities to the development of specific disorders and their co-morbidities. Such in-depth understanding of metabolic phenotypes in health and disease is crucial to enable the development of personalised medicine. Professor Orešič developed the popular MZmine open source project, a now popular software application for metabolomics data processing.

    Group Members

    Alex Dickens, D.Phil. – Postdoctoral researcher
    Santosh Lamichhane, Ph.D. – Postdoctoral researcher
    Partho Sen, Ph.D. – Postdoctoral researcher
    Andreas Bergmann Dr. rer. hum. – Postdoctoral researcher
    Tuomas Lindeman – Project engineer
    Tuulia Hyötyläinen, Ph.D., Prof. (Örebro University) – Affiliated member
    Aidan McGlinchey, Ph.D., Postdoctoral research associate (Örebro University) – Affiliated member

    Alumni

    Esko Kemppainen, Ph.D. – Postdoctoral researcher
    Krista Rantanen, Ph.D. – Project manager -Affiliated member
    Mari Päiviö, ph.D. – Postdoctoral researcher
    Tuukka Rönkkö – Project researcher

    Group members picture

    Main Ongoing Research Projects

    • Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children – PI
    • Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes – PI
    • Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) – PI
    • Strategic Research Agreement, Juvenile Diabetes Research Foundation (Integrative multi-omic study of early progression to type 1 diabetes; 2014-2017) – PI
    • pHealth Programme, multi-PI collaborative project, Academy of Finland (Personalised medicine to predict and prevent Type 1 Diabetes; 9/2015-8/2019) – Co-PI
    • EU H2020 EPoS (Elucidating Pathways of Steatohepatitis) – Workpackage leader
    • EU FP7 METSY (Integrated neuroimaging and metabolic platform for characterisation of early psychosis and prediction of patient outcomes) – Coordinator

    Honors and Awards

    Lifetime Honorary Fellow award to M. Orešič (2016, Metabolomics Society), in recognition of his groundbreaking development of metabolomics data processing tools and powerful analytical methods that have enabled systems-level investigations of processes that lead to obesity and diabetes, with a specific focus on type 1 diabetes.