Profile

    Group Leader

    Matej Orešič, Ph.D., Adjunct Professor
    matej.oresic [at] utu.fi

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    Curriculum Vitae
    Publications

    Contact Information

    Turku Bioscience
    P.O. Box 123, BioCity
    (Street addr. Tykistökatu 6 B)
    FIN-20521 Turku, Finland
    Phone: +358 44 972 6094
    Email: matej.oresic [at] utu.fi


    Description of the Research

    Systems medicine combines both systems biology and computational modelling to bring together physiological, genetic, environmental, molecular and biochemical interactions to advance the field of medicine. We focus on metabolomics applications in biomedical research and related integrative bioinformatics. We are particularly interested in the identification of vulnerabilities to disease associated with metabolic phenotypes and the underlying mechanisms linking these vulnerabilities to the development of specific disorders and their co-morbidities. Such in-depth understanding of metabolic phenotypes in health and disease is crucial to enable the development of personalised medicine. Professor Orešič developed the popular MZmine open source project, a now popular software application for metabolomics data processing.

    Group Members

    • Marina Alves, Ph.D. – Postdoctoral researcher
    • Alex Dickens, D.Phil. – Postdoctoral researcher
    • Santosh Lamichhane, Ph.D. – Academy of Finland Postdoctoral researcher
    • Partho Sen, Ph.D. – Postdoctoral researcher
    • Annie von Eyken, Ph.D. – Postdoctoral researcher
    • Tuulia Hyötyläinen, Ph.D., Prof. (Örebro University) – Affiliated member
    • Aidan McGlinchey, Ph.D., Postdoctoral research associate (Örebro University) – Affiliated member
    • Ilias Thomas, Ph.D., Postdoctoral research associate (Örebro University) – Affiliated member

    Main Ongoing Research Projects

    • Strategic Research Agreement, Juvenile Diabetes Research Foundation: Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children – PI
    • Strategic Research Agreement, Juvenile Diabetes Research Foundation: Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes – PI
    • Awards in Endocrinology & Metabolism, Novo Nordisk Foundation: Lipid pathways en route to islet autoimmunity and type 1 diabetes [starting in 2020] – PI
    • Vetenskapsrådet: Blood-based metabolomics to predict severity and patient outcomes in traumatic brain injury – PI
    • Awards in Endocrinology & Metabolism, Novo Nordisk Foundation: Metabolome en route to islet autoimmunity and type 1 diabetes – from biomarkers to metabolic pathways – PI
    • Collaborative project, EU Horizon 2020 Innovative Medicines Initiative: Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) – Metabolomics Task Force leader

    Honors and Awards

    Lifetime Honorary Fellow award to M. Orešič (2016, Metabolomics Society), in recognition of his groundbreaking development of metabolomics data processing tools and powerful analytical methods that have enabled systems-level investigations of processes that lead to obesity and diabetes, with a specific focus on type 1 diabetes.