Selected Recent Publications

    • Li, Y., Shen, K., Xiong, Z., Wu, X., Bai, J., Liu, Z., Cai, Z., Lai, Z., Xiong, C., Papageorgiou, A.,  Zhao, Z., Morozova, N.B. & Tie, D. (2026) Feasibility assessment of biodegradable Mg–Zn alloys for ureteral stents in patients with cystinuria: An in vitro study. Materials Chemistry and Physics 363, 132795 DOI

    • Premetis, G., Pantiora, P., Poudel, N., Georgakis, N.,  Tzanetopoulou, E.-E., Papageorgiou, A.C., and Labrou, N.E. (2026) Antimicrobial peptide fusion and alginate encapsulation broaden the antibacterial spectrum and preserve storage stability of the endolysin AbLys1 from Acinetobacter baumannii phage AbTZA1. ACS Omega 11, 35326 DOI

    • Li, Y., Lu, C., Shen, K., Wu, X., Bai, J., Liu, Z., Cai, Z., Liu, W., Xiong, C., Papageorgiou, A., Zhao, Z., Borisovna Morozova, N., Staiger, M. & Tie, D. (2026) Biodegradable behavior and mechanical performance of Mg-Zn alloys in acidic urinary environments relevant to renal tubular acidosis. Progress in Natural Science: Materials International (in press) DOI

    • Wang, X., Yang, J., Rosqvist, E., Lyu, Y., Papageorgiou, A.C., Peltonen, J., Mäkilä, E., Cheng, F. &  Li, J. (2026) Isomeric cues direct macrocycle selection from complex chemical systems for selective separation and recycling. Cell Rep Phys Sci 7, 103140 DOI
    •  Michlmayr, H. & Papageorgiou, A.C. (2026) Author response to “Commentary on detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat” by Dr. Latika Shendre. J. Biol Chem 302(2):111139 Pubmed
    • Bodourian, C.S., Imran, M., Georgakis, D.G., Papageorgiou, A.C. & Labrou, N.E. (2025) Structural and functional characterization of a metagenomically-derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase. Protein Sci 34, e70396 Pubmed
    • Yang, J., Wang, X., Wu, X., Lyu, Y., Papageorgiou, A.C., Mäkilä, E. & Li., J. (2025) Oxidation Driven Synthetic Molecular Networks Enable Dynamic Assembly and Fluorescence Modulation in Living Cells. Cell Rep Phys Sci, 102922 DOI
    • Kontouri, A., Georgakis, N., Papageorgiou, A.C. & Labrou, E. (2025) Functional Characterization and Directed Evolution of Cicer arietinum Glutathione Transferases for Enhanced Hydroperoxidase Activity and Ligandin Function. Phytochemistry 242, 114692 Pubmed DOI
    • Michlmayr, H., Siller, , Kenjeric, L., Doppler, M., Malachova, A., Hofer, M., Hametner, C., Schweiger, W., Steiner, B., Kugler, K.G., Mayer, K.F.X., Hermann Buerstmayr, H., Schuhmacher, R., Krska, R., Labrou, N.E., Papageorgiou, A.C. & Adam, G. (2025) Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat. J. Biol. Chem. 110600 Pubmed DOI
    • Wu, X., Zhu, C., Wang, Z., Yang, L., Liu, F., Chen, J., Nuriddinov, K., Giyasov, S., Morozova, N. B., Shi, W., Lu, C., Papageorgiou, A., & Tie, D. (2025). Rheological Behaviors of Rubber-Modified Asphalt Under Complicated Environment. Polymers, 17 (13), 1753 DOI
    • Nokas, D., Panagiotopoulou E., Kapogiannatos A., Premetis G., Labrou, N.E., Efthimiadou, E.K., Papageorgiou, A.C. & Chronopoulou, E.G. (2025) Biochemical and structural characterization of the metagenome-derived chlorite dismutase enzyme from Pseudomonas sp. FEBS J. Pubmed DOI
    • Tuna, A., Papageorgiou, A.C., Peuronen, A., Peljo, P. & Knör, G. (2025) mer-[InCl3(C5D5N)3]2·C5D5N: A New d5-pyridine Derivative of Indium(III) Chloride Complex. J. Turk. Chem. Soc. Sect. A: Chem. 12, 15–22 DOI
    • Yang, J., Wang, X., Wu, X., Lyu, Y., Papageorgiou, A. C., & Li, J. (2025) Quantitative synthesis of dynamic combinatorial macrocycles accelerated by preorganization of AIEgens for live visualization of drug release. Cell Rep. Phys. Sci. 6(1), 102355 DOI 
    • Sabt, A., Kitsos, S., Ebaid, M.S., Furlan, V.,  Pantiora, P. D., Tsolka, M., Elkaeed, E.B., Hamissa, M.F., Angelis, N., Tsitsilonis, O.E., Papageorgiou, A.C., Bren, U. & Labrou, N.E. (2024) Novel Coumarin-6-Sulfonamide-Chalcone Hybrids as Glutathione Transferase P1-1 Inhibitors. PLoS ONE 19(8): e0306124 Pubmed DOI
    • Tsouri, S., Tselo, E., Premetis, G. E., Furlan, V., Pantiora, P. D., Mavroidi, B., et al. (2024) A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide. Pharmaceuticals 17 (3), 365
    • Varotsou, C., Ataya, F., Papageorgiou, A.C. & Labrou, N.E. (2024) Structural studies of Klebsiella pneumoniae fosfomycin-resistance protein and its application for the development of an optical biosensor for fosfomycin determination. Int J Mol Sci 25 (1), 85 Pubmed DOI
    • Premetis, E.G., Stathi, A., Papageorgiou, A.C. & Labrou, N.E. (2023) Structural and Functional Features of a Broad-Spectrum Prophage-Encoded Enzybiotic from Enterococcus Faecium. Sci Rep 13, 7450 Pubmed
    • Kupreienko, O., Pouliou, F., Constandinidis, C., Axarli, I., Douni, E., Papageorgiou, A.C. Nikolaos E. Labrou, N.E. (2023) Inhibition Analysis and High-resolution Crystal Structure of Mus musculus Glutathione Transferase P1-1. Biomolecules, 13(4), 613 DOI
    • Chronopoulou, E.G., Mutabdzija, L., Poudel, N., Papageorgiou, A.C. & Labrou, N.E. (2023) A key role in catalysis and enzyme thermostability of a conserved helix H5 motif of human glutathione transferase A1-1. Int J Mol Sci 24(4):3700 Pubmed
    • Pantiora, P., Furlan, V., Matiadis, D., Mavroidi, B., Perperopoulou, F., Papageorgiou, A.C., Sagnou, M., Bren, U., Pelecanou, M. & Labrou, N.E. (2023) Monocarbonyl curcumin analogues as potent inhibitors against human glutathione transferase P1-1. Antioxidants 12(1):63 Pubmed
    • Premetis, E.G., Stathi, A., Papageorgiou, A.C & Labrou, N.E. (2022) Characterization of a glycoside hydrolase endolysin from Acinetobacter baumannii phage AbTZA1 with high antibacterial potency and novel structural features. FEBS J. doi: 10.1111/febs.16686 Pubmed
    • Lyu, Y., Wu, X., Papageorgiou, A.C., Yang; J., Wang; X., Qi, D., Li J. (2022) Dynamic Covalent Macrocycles Co-delivering Genes and Drugs against Drug-Resistant Cancer. Cell Rep Phys Sci 3, 101150 DOI
    • Yu, J., Qi, D., Mäkilä, E., Lassila, L., Papageorgiou, A.C., Peurla, M., Rosenholm, J., Zhao, Z., Vallittu, P., Jalkanen, S., Jia, C., and Li, J. (2022) Supramolecular Plastics Processed from Small Molecule-based Coacervates. Angew. Chem. Int. Ed. 61 (39) DOI: 10.1002/anie.202204611 Pubmed
    • Ioannou, E., Papageorgiou, A.C. and Labrou, N.E. (2022) Directed Evolution of Phi Class Glutathione Transferases Involved in Multiple-Herbicide Resistance of Grass Weeds and Crops. Int. J. Mol. Sci., 23(13), 7469 Pubmed
    • Bodourian, C.S., Poudel, N., Papageorgiou, A.C., Antoniadi, M., Georgakis, N.D., Abe, H. & Labrou, N.E. (2022) Ligandability Assessment of Human Glutathione Transferase M1-1 using Pesticides as Chemical Probes. Int. J. Mol. Biol. 25;23(7):3606 Pubmed
    • Yu, J., Qi, D., Mäkilä, E., Lassila, L., Papageorgiou, A.C., Peurla, M., Rosenholm, J., Zhao, Z., Vallittu, P., Jalkanen, S., Jia, C., and Li, J. (2022) Supramolecular Plastics Processed from Small Molecule-based Coacervates. ChemRxiv. doi:10.26434/chemrxiv-2022-snwcn (this content is a preprint and has not been peer-reviewed)
    • Yu, W., Mohsin, I., Papageorgiou, A.C. & Li, D.-C. (2022) Purification and structural characterization of the native AA9 lytic polysaccharide monooxygenase from Thermoascus aurantiacus and identification of its C1- and C4-oxidized reaction productions. Catalysts 12, 139 DOI
    • Perperopoulou, F., Poudel, N., Ataya, F., Papageorgiou, A.C. & Labrou, N.E. (2022) Structural and functional characterization of Camelus dromedarius Glutathione transferase M1-1. Life 12(1), 106 Pubmed
    • Mohsin, I. & Papageorgiou, A.C. (2022) Fungal extremozymes: A potential bioresource for green chemistry. In: Sahay, S. (eds) Extremophilic Fungi. Springer, Singapore DOI
    • Papageorgiou, A. C. (2022) Structural characterization of multienzyme assemblies: An overview. Methods Mol Biol 2487:51-72 Pubmed
    • Perperopoulou, F., Fragoulaki, M., Papageorgiou, A.C. & Labrou, N.E. (2021) Directed evolution of a glutathione transferase for the development of a biosensor for alachlor determination. Symmetry 13 (3), 461 DOI
    • Mohsin, I., Zhang, L.-Q., Li, D.-C.& Papageorgiou, A.C. (2021) Crystal structure of a Cu,Zn superoxide dismutase from the thermophilic fungus Chaetomium thermophilum. Protein Pept. Lett 28, 1043-1053 Pubmed
    • Platis, M., Vlachakis, D., Foudah, A.I., Muharram, M.M, Alqarni, M.H., Papageorgiou, A.C. & Labrou, N.E. (2021) The interaction of Schistosoma japonicum glutathione transferase with Cibacron blue 3GA and its fragments. Med Chem 7, 332-343 Pubmed
    • Georgakis, N., Poudel, N., Vlachakis, D., Papageorgiou, A.C. & Labrou, N.E. (2021) Phi class glutathione transferases as molecular targets towards multiple-herbicide resistance: Inhibition analysis and pharmacophore design. Plant Physiol Biochem 158, 342-352 Pubmed
    • Papageorgiou, A.C., Poudel, N. & Matsson, J. (2021) Protein structure analysis and validation with X-ray crystallography. Methods Mol. Biol 2178, 377-404  Pubmed
    • Papageorgiou, A.C. & Mohsin, I. (2020) The SARS-CoV-2 spike glycoprotein as a drug and vaccine target: Structural insights into its complexes with ACE2 and antibodies. Cells 9, 2343 Pubmed
    • Johansson M.M., Bélurier E., Papageorgiou A.C., Sundin A.P., Rahkila J., Kallonen T., Nilsson U.J., Maatsola S., Nyholm T.K.M., Käpylä J., Corander J., Leino R., Finne J., Teneberg S. & Haataja S. (2020) The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease. J. Biol. Chem. 295, 14304-14324 Pubmed
    • Premetis,G., Marugas, P., Fanos, G., Vlachakis, D., Chronopoulou, E.G., Perperopoulou, F., Dubey, K.K., Shukla, P., Foudah, A.I., Muharram, M.M., Aldwsari, M.F., Papageorgiou, A.C. & Labrou, N.E. (2020) The interaction of the microtubule targeting anticancer drug colchicine with human glutathione transferases. Curr Pharm Des 26, 5205-5212 Pubmed
    • Wang, L., Borghei, M., Ishfaq, A., Lahtinen, P., Ago, M., Papageorgiou, A.C., Lundahl, M., Johansson, L.S., Kallio, T. & Rojas, O.J. (2020) Mesoporous carbon microfibers for electroactive materials derived from lignin-containing nanocellulose ACS Sustain Chem Eng 8, 8549-8561
    • Georgakis; N., Poudel, N., Papageorgiou, A.C. & Labrou, N.E. (2020) Comparative structural and functional analysis of phi class glutathione transferases involved in multiple-herbicide resistance of grass weeds and crops. Plant Physiol Biochem 149, 266-276 Pubmed
    • Siddiqui, F.A., Alam, C., Rosenqvist, P., Ora, M., Sabt, A., Manoharan, G., Bindu, L., Okutachi, S., Catillon, M., Taylor, T., Abdelhafez, O.M., Lönnberg, H., Stephen, A.G., Papageorgiou, A.C., Virta, P. & Abankwa, D. (2020) PDE6D inhibitors with a new design principle selectively block K-Ras activity ACS Omega 5, 832-842 Pubmed
    • Mohsin, I., Poudel, N., Li, D.-C. & Papageorgiou, A.C. (2019) Crystal structure of a GH3 b-glucosidase from the thermophilic fungus Chaetomium thermophilum. Intern J Mol Sci 20, 5962 Pubmed
    • Wang, L., Lundahl, M.J., Greca, L.G., Papageorgiou, A.C., Borghei, M. & Rojas, O.M. (2019) Effects of non-solvents and electrolytes on the formation and properties of cellulose I filaments  Sci Reports 9, 16691 Pubmed
    • Papageorgiou, A.C. (2019) X-ray crystallography in structure-function characterization of therapeutic enzymes Adv Exp Med Biol 1148, 81-10 Pubmed
    • Li, D.-C & Papageorgiou, A.C. (2019). Cellulases from thermophilic fungi: Recent insights and biotechnological applications In Extreme Environments: Ecological Role and Biotechnological Significance ed. S. Tiquia-Arashiro & Grube, M., Springer International Publishing
    • Wang. L., Ago, M., Borghei, M., Ishaq, A., Papageorgiou, A.C., Lundahl, M. & Rojas, O.M. (2019) Conductive carbon microfibers derived from wet-spun lignin/nanocellulose hydrogels. ACS Sustain Chem Eng 7 (6), 6013-6022 Link
    • Theoharaki, C., Chronopoulou, E., Vlachakis, D., Ataya, F.S., Giannopoulos, P., Mavrikou, S., Skopelitou, K., Papageorgiou, A.C. & Labrou, N.E. (2019) Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora. Funct. Integr. Genomics 19:1-12  Pubmed
    Last updated on August 3, 2026