Genome function is directed by epigenetic regulation through chemical modifications of DNA, DNA bound proteins and by miRNAs. Epigenetic regulation is crucial for the proper development and function of cells and tissues. Epigenetic modifications regulate organization and packaking of chromatin and control activity and accessibility of important functional elements of the genome, such as promoters and enhancers. Epigenetic regulation is sensitive to environmental and life style factors, which can cause both temporary and long-term changes in the genome. These changes can further influence development, traits and health of an individual.
Our next-generation sequencing based solutions for epigenome analysis include:
- Reduced Representation Bisulfite Sequencing (RRBS)
- Whole Genome Bisulphite Sequencing (WGBS)
- miRNA sequencing
The service includes QC analysis of the DNA, library preparation, next-generation sequencing and raw data QC. For further information please fill in our NGS Project Request Form or send an email to email@example.com, and we will contact you as soon as possible.
Histone modification analysis is currently not provided as a routine service. If you are interested in this application, please, contact us for consultation or to discuss about possibilites for research collaboration.