Selected publications and preprints

    Prasannakumar Deshpande, Dani Flinkman, Ye Hong, Elena Goltseva, Valentina Siino, Lihua Sun, Sirkku Peltonen, Laura Elo, Valtteri Kaasinen, Peter James, Eleanor T. Coffey. Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2. 2020 BioRxiv. Preprint

    Emilia Komulainen, Artemis Varidaki, Natalia Kulesskaya, Hasan Mohammad, Christel Sourander, Heikki Rauvala, Eleanor T Coffey. Impact of JNK and its substrates on dendritic spine morphology. Cells 2020 9(2): 440. Pubmed

    Hollos P, John JM, Lehtonen, J, Coffey E. Optogenetic control of spine-head JNK reveals a role in dendritic spine regression. eNeuro 2020 Jan. Pubmed

    David J, Gormley S, McIntosh AL, Kebede V, Thuery G, Varidaki A, Coffey ET, Harkin A. L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents. Behav Brain Res. 2019 Apr 19;362:90-102. Pubmed.

    Hollos P, Marchisella F, Coffey ET. JNK Regulation of Depression and Anxiety. Brain Plasticity, vol. Pre-press, no. pp. 1-11, 2018. Download

    Varidaki A, Hong Y, Coffey ET. Repositioning Microtubule Stabilizing Drugs for Brain Disorders. Front Cell Neurosci. 2018 Aug 8;12:226. Pubmed.

    Mohammad H, Marchisella, F, Ortega-Martinez S, Hollos P, Eerola K, Komulainen E, Kulesskaya N, Freemantle E, Fagerholm V, Savbontaus E, Rauvala H, Peterson BD, van Praag H, Coffey ET. JNK1 controls adult hippocampal neurogenesis and imposes cell autonomous control of anxiety behaviour from the neurogenic niche. Molecular Psychiatry. 2018, 23(2):487.  Pubmed

    Jadhav S, Gulumkar V, Deshpande P, Coffey ET, Lönnberg H, Virta P Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for “Click”- Conjugation with Fluorescent Labels and Oligonucleotides. Bioconjug Chem. 2018 Jun 15. doi: 10.1021/acs.bioconjchem.8b00317. Pubmed

    Marchisella, F., Coffey, E.T. , Hollos, P. Microtubule and microtubule associated protein anomalies in psychiatric disorders. Cytoskeleton. Special review issue on Emerging Concepts in Neuronal Cytoskeleton. 2016 73(10):596-611. doi: 10.1002/cm.21300. Review

    Padzik A, Deshpande P, Hollos P, Franker M, Rannikko E, Cai D, Prus P, Mågard M, Westerlund N, Verhey K, James P, Hoogenraad C, Coffey ET. KIF5C S176 phosphorylation regulates microtubule binding and transport efficiency in neurons. Frontiers in Cellular Neuroscience. 2016 Mar 15;10:57. Pubmed

    Varidaki, A, Mohammad, H, Coffey, ET. Molecular Mechanisms of Depression. Systems Neuroscience in Depression. Elsevier Edited by Frodl, T. 2016 Download

    Ortega-Martinez, S. A new perspective on the role of CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Frontiers in Molecular Neuroscience. 2015 26, 8,46.

    Komulainen, E, Zdrojewska, J, Freemantle, E, Mohammad, H, Marchisella, F, Kulesskaya, N, Mysore, R, Deshpande, P, Michelson, K, Måberg, M, Rauvala, H, James, P, Coffey, E. JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size and influences fine motor coordination. Frontiers in Cellular Neuroscience. 2014 8, 272: doi: 10.3389/fncel.2014.00272.  Pubmed

    Coffey E.T.  Nuclear and cytosolic JNK signalling in neurons. Nature Reviews Neuroscience 2014 15(5):285-99. Pubmed

    Zdrojewska J, Coffey ET. The impact of JNK on neuronal migration. Advances in Experimental Medical Biology. 2014;800:37-57. Review. Pubmed

    Björkblom B*, Padzik A*, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET. JNK Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells. Molecular and Cellular Biology. 2012 32(17):3513-26. Pubmed

    Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Björkblom B, Coffey ET, Gudlaugsson E, Smaaland R, Janssen EA, Baak JP. The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer. Breast Cancer Research and Treatment. 2012 Jul 8. [Epub ahead of print] Pubmed

    Mai, A., Veltel, S., Pellinen, T., Padzik, A., Coffey, E., Marjomäki, V., Ivaska, J. Competetive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. Journal of Cell Biology. 194(2), 291-306, 2011.

    Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nature Neuroscience. 14, (3), 305-13, 2011. Pubmed

    Matlawska-Wasowska K, Finn R, Mustel A, O’Byrne CP, Baird AW, Coffey ET, Boyd A. The vibrio parahaemolyticus Type III secretion systems manipulate host cell MAPK for critical steps in pathogenesis. BMC Microbiology. Dec 30th, 2010

    Microtubule stabilization by BMP receptor-mediated scaffolding of JNK promotes dendrite formation. Podkowa M, Zhao X, Chow CW, Coffey ET, Davis RJ, Attisano L. Molecular and Cellular Biology. 2010

    Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. (2009) Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. Nature Neuroscience. 12(7):864-71. Pubmed

    Waetzig, V, Wacker, U, Haeusgen, Björkblom,B, Courtney, M.J., Coffey, E.T. Herdegen, T. (2009) Concurrent protective and destructive signalling of JNK2 in neuroblastoma cells. Cellular Signalling. 873-880.

    Naumanen, T., Johansen, L.D., Coffey, E.T., Kallunki, T. (2008) Loss of function of IKAP/ELP1: Could neuronal migration defect underlie familial disautonomia? Cell Adhesion and Migration. Vol.2, Issue 4.

    Benny Björkblom, Jenni C. Vainio, Vesa Hongisto, Thomas Herdegen, Michael Courtney, Eleanor Coffey. (2008) All JNKs can kill but nuclear localization is critical for neuronal death. Journal of Biological Chemistry. 283(28)19704-13.

    Hongisto, V., Vainio, J.C., Thompson, R., Courtney, M.J., Coffey, E.T. (2008) The Wnt pool of GSK-3-beta is critical for trophic deprivation induced neuronal death. Molecular and Cellular Biology 28(5)1515-27. PDF

    Dan Johansen, L.,  Naumanen, T., Knudsen, A., Westerlund, N., Gromova, I., Junttila, M., Nielsen, C., Bottzauw, T., Tolkovsky, A., Westermarck, J., Coffey, E.T., Jäättelä, M., Kallunki, T. (2008) IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. Journal of Cell Science 121(6) 854-64.

    Westerlund, N., Zdrojewska, J., Courtney, M.J., Coffey, E.T. (2008) SCG10 as a molecular effector of JNK1: Implications for the therapeutic targeting of JNK in nerve regeneration. Expert Opinion on Therapeutic Targets 12(1):31-43.  PDF

    Semenova, M.M., Mäki-Hokkonen, A.M.J., Cao, J., Komarovski, V., Forsberg, M., Koistinaho, M., Coffey, E.T., Courtney, M.J. (2007) Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. Nature Neuroscience 10,(4):436-443

    Tararuk, R., Östman, N., Li, W., Björkblom, B., Padzik, A., Zdrojewska, J., Hongisto, V., Herdegen, T., Konopka, W., Courtney, M.J., Coffey, E.T. (2006) JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. Journal of Cell Biology 173(2):265-77

    Björkblom, B., Östman, N., Hongisto, V., Komarovski, V., Filen, J., Nyman, T., Kallunki, T., Courtney, M., Coffey, E. (2005) Constitutively active cytoplasmic JNK1 is a dominant regulator of dendritic architecture; role of MAP2 as an effector. Journal of Neuroscience 25(27):6350-6361

    Yang J, Lindahl M, Lindholm P, Virtanen H, Coffey E, Runeberg-Roos P, Saarma M. (2004) PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. FEBS Lett. 569:267-271

    Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ. (2004) Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinase s in different forms of apoptotic neuronal death. Journal of Biological Chemistry 279:35903-35913

    Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ, Coffey ET. (2003) Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Molecular Cell Biology 23:6027-6036

    Coffey E.T., Smiciene G., Hongisto V., Cao J., Brecht S., Herdegen T., Courtney M.J. (2002) c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. Journal of  Neuroscience 22:4335-4345

    Hietakangas V, Elo I, Rosenstrom H, Coffey ET, Kyriakis JM, Eriksson JE, Sistonen L. (2001) Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform. FEBS Lett. 505:168-172

    Coffey, E.T., Hongisto, V., Dickens, M., Davis, R.J. and Courtney, M.J. (2000) Dual Roles for c-Jun N-terminal Kinase in Developmental and Stress Responses in Cerebellar granule Neurons. Journal of Neuroscience 20, 7602–7613

    Courtney, M.J. and Coffey, E.T. (1999) The mechanisms of ARA-C induced apoptosis of differentiating cerebellar granule neurons. European Journal of Neuroscience. 11:1073-1084

    Courtney, M.J., Åkerman, K.E.O. and Coffey, E.T. (1997) Neurotrophins protect cultured cerebellar granule cells against the early phase of cell death by a two-component mechanism. Journal of Neuroscience 17, 4201-4211

    Coffey ET, Akerman KE, Courtney MJ. (1997) Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells. Neuroscience Letters. 227:177-180