Organisation of Signalling Pathways – Roles in Disorders of the Nervous System

• NOS1AP/CAPON: mechanisms of action on NMDA receptor signalling through nNOS (review)
• NOS1AP/CAPON : contribution to diseases and disorders (hypoxia-ischaemia, neuropathic pain, schizophrenia, neurodegenerative disorders)

An Optogenetic and Optopharmacological toolbox for precise control of cell signalling pathways

• OptoJNKi and Optop38i, new tools for precise spatiotemporal control of JNK and p38 pathways (see www.nature.com/articles/ncomms15017, press release, plasmids)
• A novel design strategy for rapid generation of optically regulated inhibitors – extending the toolbox

Development of High-Content Analysis and High-Throughput Microscopy tools and methods

• Applications for signalling pathways and neuroscience
• Workshops: check back later for the next workshop (last workshop was 19-20 June 2017)
• Provision of high-throughput infrastructure and services for biological research, chemical biology and early-stage drug discovery (Screening unit)