Candemir E, Fattakhov N, Leary AO, Slattery DA, Courtney MJ, Reif A, Freudenberg F. Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice. Eur Neuropsychopharmacol. 2022 Dec 10;67:66-79. doi: 10.1016/j.euroneuro.2022.11.006. Epub ahead of print. PMID: 36513018.


    Freudenberg F, Candemir E, Chen X, Li LL, Esen-Sehir D, Schenk N, Kinoshita M, Grünewald L, Frerichs V, Fattakhov N, Manchen J, Bikas S, Kumar A, OLeary A, Slattery DA, von Engelhardt J, Courtney MJ, Reif A. Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. EBioMedicine. 2021 Sep;71:103565. doi: 10.1016/j.ebiom.2021.103565. Epub 2021 Aug 27. PMID: 34455393; PMCID: PMC8403735.


    Li LL, Klein FM Li Greci L, Popinigis A, Freudenberg F, Courtney MJ Resonance energy transfer sensitizes and monitors in situ switching of LOV2-based optogenetic actuators. Nat. Commun. 2020 Oct 9;11(1):5107. doi: 10.1038/s41467-020-18816-8. PMID: 33037199; PMCID: PMC7547724.

    Li LL, Courtney MJ RET-enhanced measurement of relaxation time constants of LOV2-based optogenetic actuators. Protoc. Exch., in press. 


    Esen-Sehir D, Courtney MJ, Bittner RA, Reif A, Freudenberg F. (2019) Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice. 2019 Dec;31(6):305-315.
    doi: 10.1017/neu.2019.31. PMID: 31364522.


    Robinson S and Courtney MJ (2018) Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields. Bioinformatics, Sep 15;34(18):3196-3204.
    doi: 10.1093/bioinformatics/bty322. PMID: 29897415.

    Lee WH, Carey LM, Li LL, Xu Z, Lai YY, Courtney MJ, Hohmann A. (2018) ZLc002, a putative small molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. Mol Pain. Aug 29:1744806918801224.
    doi: 10.1177/1744806918801224. PubMed PMID: 30157705.

    Lee WH, Li LL, Chawla A, Hudmon A, Lai YY, Courtney MJ, Hohmann AG. (2018) Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice. Pain.  May;159(5):849-863.
    doi: 10.1097/j.pain.0000000000001152. PMID: 29319606.  press release


    Melero-Fernandez de Mera RM*, Li LL*, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ (2017) A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs. (*equal contribution) Nat. Commun. 8, 15017.
    doi: 10.1038/ncomms15017. PMID: 28497795press release

    Li LL, Cisek K, Courtney MJ (2017) Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element. Front. Mol. Neurosci. 10:58.
    doi: 10.3389/fnmol.2017.00058. PMID: 28360833.

    von Ossowski L, Li LL, Möykkynen T, Coleman SK, Courtney MJ, Keinänen K. (2017) Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. PLoS One. Feb 2;12(2):e0171489.
    doi: 10.1371/journal.pone.0171489. PMID: 28152104.


    Kamiya T, Courtney M, Laukkanen MO (2016) Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death. Oxid Med Cell Longev. 2016:8479718.
    doi: 10.1155/2016/8479718. PubMed PMID: 28101299

    Lehtonen S, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G (2016) Inhibition of excessive oxidative protein folding is protective in MPP+ toxicity-induced PD models. Antioxidants & Redox Signaling. 25(8): 485-497.
    doi: 10.1089/ars.2015.6402. PMID: 27139804.

    Ba W, Selten MM, van der Raadt J, van Veen H, Li LL, Benevento M, Oudakker AR, Lasabuda RS, Letteboer SJ, Roepman R, van Wezel RJ, Courtney MJ, van Bokhoven H, Nadif Kasri N (2016) ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function. Cell Rep. 14, 1355-1368.
    doi: 10.1016/j.celrep.2016.01.037 PMID: 26854232


    Li LL, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ (2015) Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models. J Neurosci. 35, 7349-7364.
    doi: 10.1523/JNEUROSCI.0037-15.2015 PMID: 25972165 press release


    Courtney MJ, Li LL, Lai YY (2014) Mechanisms of NOS1AP action on NMDA receptor-nNOS signalling. Front Cell Neurosci. 8:252.
    doi:  10.3389/fncel.2014.00252 PMID: 25221472

    Tortoriello G, Morris C, Alpar A, Fuzik J, Shirran SL, Calvigione D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J. 33:668-85.
    doi:  10.1002/embj.201386035 PMID: 24469251


    Li LL, Ginet V, Liu X, Vergun O, Tuittila M, Mathieu M, Bonny C, Puyal J, Truttmann AC, Courtney MJ (2013) The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. J Neurosci. 33, 8185-8201.
    doi: 10.1523/JNEUROSCI.4578-12.2013 PMID: 23658158 press release

    2012 and earlier

    D’Orsi B, Bonner H, Tuffy LP, Düssmann H, Woods I, Courtney MJ, Ward MW, Prehn JH (2012) Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis. J Neurosci. 32, 1847-1858.
    doi: 10.1523/JNEUROSCI.2345-11.2012. PMID: 22302823

    Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET (2012) JNK phosphorylation of marcksl1 determines actin stability and migration in neurons and in cancer cells. Mol Cell Biol. 32, 3513-26. PMID: 22751924

    Yang H, Courtney MJ, Martinsson P, Manahan-Vaughan D (2011) Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats. Eur J Neurosci. 33, 1647-1655.
    doi: 10.1111/j.1460-9568.2011.07661.x. PMID: 21453290

    Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ and Coffey E.T. (2011) Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci. 14, 305-313. PMID: 21297631

    Hellwig CT, Kohler BF, Lehtivarjo AK, Dussmann H, Courtney MJ, Prehn JH, Rehm M. Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. J Biol Chem. 2008 Aug 1;283(31):21676-85. PMID: 18522940

    Björkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ*, Coffey ET*. All JNKs can kill, but nuclear localization is critical for neuronal death. (*equal contribution) J Biol Chem. 2008 Jul 11;283(28):19704-13. PMID: 18474608

    Hongisto V, Vainio JC, Thompson R, Courtney MJ, Coffey ET. The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death. Mol Cell Biol. 2008 Mar;28(5):1515-27. PMID: 18195042

    Semenova MM*, Mäki-Hokkonen AM*, Cao J*, Komarovski V, Forsberg KM, Koistinaho M, Coffey ET, Courtney MJ. Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. (*equal contribution) Nat Neurosci. 2007 Apr;10(4):436-43. PMID: 17369826

    Tararuk T, Ostman N, Li W, Björkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W, Courtney MJ, Coffey ET. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol. 2006 Apr 24;173(2):265-77. PMID: 16618812

    Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML, Courtney MJ. The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol. 2005 Jan 3;168(1):117-26. PMID: 15631993

    Björkblom B, Ostman N, Hongisto V, Komarovski V, Filén JJ, Nyman TA, Kallunki T, Courtney MJ, Coffey ET. Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci. 2005 Jul 6;25(27):6350-61. PMID: 16000625

    Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ. Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem. 2004 Aug 20;279(34):35903-13. PMID: 15192112

    Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ, Coffey ET. Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3.Mol Cell Biol. 2003 Sep;23(17):6027-36. PMID: 12917327

    Coffey ET, Smiciene G, Hongisto V, Cao J, Brecht S, Herdegen T, Courtney MJ. c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J Neurosci. 2002 Jun 1;22(11):4335-45. PMID: 12040039

    Solovyan VT, Bezvenyuk ZA, Salminen A, Austin CA, Courtney MJ. The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J Biol Chem. 2002 Jun 14;277(24):21458-67. PMID: 11940566

    Coffey ET, Hongisto V, Dickens M, Davis RJ, Courtney MJ. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. J Neurosci. 2000 Oct 15;20(20):7602-13. PMID: 11027220

    Courtney MJ, Coffey ET. The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons. Eur J Neurosci. 1999 Mar;11(3):1073-84. PMID: 10103100

    Courtney MJ, Akerman KE, Coffey ET. Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism. J Neurosci. 1997 Jun 1;17(11):4201-11. PMID: 9151737