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    Publications

    1. Momeny M, Tienhaara M, Sharma M, Chakroborty D, Varjus R, Takala I, Merisaari J, Padzik A, Vogt A, Paatero I, Elenius K, Laajala TD, Kurppa KJ, Westermarck J. DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer. EMBO Mol Med. 2024 Jul;16(7):1603-1629. doi: 10.1038/s44321-024-00088-0. Epub 2024 Jun 17. PMID: 38886591; PMCID: PMC11251193.
    2. Ali AE, Li LL, Courtney MJ, Pentikäinen OT, Postila PA. Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1. Brief Bioinform. 2024 Sep 23;25(6):bbae458. doi: 10.1093/bib/bbae458. PMID: 39311700; PMCID: PMC114182
    3. Lorenza Cutrone, Hedvig Djupenström, Jasmin Peltonen, Elena Martinez Klimova, Simona Corso, Silvia Giordano, Lea Sistonen, Silvia Gramolelli Heat shock factor 2 positively regulates oncogenic herpesvirus gene expression by remodeling the chromatin landscape bioRxiv 2024.11.22.624798; doi: https://doi.org/10.1101/2024.11.22.624798
    4. Li LL, Klein FM, Li Greci L, Popinigis A, Freudenberg F, Courtney MJ. Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators. Nat Commun. 2020 Oct 9;11(1):5107. doi: 10.1038/s41467-020-18816-8. PMID: 33037199; PMCID: PMC7547724.
    5. Lee WH, Li LL, Chawla A, Hudmon A, Lai YY, Courtney MJ, Hohmann AG. Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice. Pain. 2018 May;159(5):849-863. doi: 10.1097/j.pain.0000000000001152. PubMed PMID: 29319606; PubMed Central PMCID: PMC6085107.
    6. Robinson S, Courtney MJ. Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields. Bioinformatics. 2018 Apr 20. doi: 10.1093/bioinformatics/bty322. PubMed PMID: 29897415.; PubMed Central PMCID: PMC5988776 PMID: 29897415.
    7. Lee WH, Carey LM, Li LL, Xu Z, Lai YY, Courtney MJ, Hohmann A. ZLc002, a putative small molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. Mol Pain. 2018 Aug 29:1744806918801224. doi: 10.1177/1744806918801224. PubMed PMID: 30157705.
    8. Li LL, Cisek K, Courtney MJ (2017) Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element. Front. Mol. Neurosci. 10:58. doi: 10.3389/fnmol.2017.00058. PMID: 28360833.
    9. Melero-Fernandez de Mera RM*, Li LL*, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ (2017) A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs. (*equal contribution) Nat. Commun. 8, 15017. doi: 10.1038/ncomms15017. PMID: 28497795.
    10. Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson’s Disease Models. Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. doi: 10.1089/ars.2015.6402. Epub 2016 Jun 15. PMID: 27139804.
    11. Li LL, Melero-Fernandez de Mera RM, Chen J, Ba W, Nadif Kasri N, Zhang M, Courtney MJ (2015) Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models. J Neurosci. 35, 7349-7364. doi: 10.1523/JNEUROSCI.0037-15.2015 PMID: 25972165
    12. Li LL, Ginet V, Liu X, Vergun O, Tuittila M, Mathieu M, Bonny C, Puyal J, Truttmann AC, Courtney MJ (2013) The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. J Neurosci. 33, 8185-8201. doi: 10.1523/JNEUROSCI.4578-12.2013 PMID: 23658158