Publications

    2023.

    • Pavic K, Gupta N, Omella JD, Derua R, Aakula A, Huhtaniemi R, Määttä JA, Höfflin N, Okkeri J, Wang Z, Kauko O, Varjus R, Honkanen H, Abankwa D, Köhn M, Hytönen VP, Xu W, Nilsson J, Page R, Janssens V, Leitner A, Westermarck J. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nat Commun. 2023 Feb 28;14(1):1143. doi: 10.1038/s41467-023-36693-9. PMID: 36854761 https://pubmed.ncbi.nlm.nih.gov/36854761/

    2022.

    • Peuhu E, Jacquemet G, Scheele CLGJ, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. Dev Cell. 2022 Oct 24;57(20):2350-2364.e7. doi: 10.1016/j.devcel.2022.09.016. PMID: 36283390 https://pubmed.ncbi.nlm.nih.gov/36283390/
    • Al-Akhrass H, Pietilä M, Lilja J, Vesilahti EM, Anttila JM, Haikala HM, Munne PM, Klefström J, Peuhu E, Ivaska J. Sortilin-related receptor is a druggable therapeutic target in breast cancer. Mol Oncol. 2022 Jan;16(1):116-129. doi: 10.1002/1878-0261.13106. Epub 2021 Oct 10. PMID: 34564954 https://pubmed.ncbi.nlm.nih.gov/34564954/
    • Vaparanta K, Jokilammi A, Tamirat M, Merilahti JAM, Salokas K, Varjosalo M, Ivaska J, Johnson MS, Elenius K. An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation. Nat Commun. 2022 Nov 14;13(1):6953. doi: 10.1038/s41467-022-34539-4. PMID: 36376313 https://pubmed.ncbi.nlm.nih.gov/36376313/
    • Närvä E, Taskinen ME, Lilla S, Isomursu A, Pietilä M, Weltner J, Isola J, Sihto H, Joensuu H, Zanivan S, Norman J, Ivaska J. MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels. iScience. 2022 May 25;25(6):104459. doi: 10.1016/j.isci.2022.104459. eCollection 2022 Jun 17. PMID: 35677646 https://pubmed.ncbi.nlm.nih.gov/35677646/
    • Aakula A, Isomursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, Li SP, Trotman L, Taimen P, Rannikko A, Lammerding J, Paatero I, Mirtti T, Ivaska J, Westermarck J. PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers. Mol Oncol. 2022 Dec 3. doi: 10.1002/1878-0261.13353. Online ahead of print. PMID: 36461911 https://pubmed.ncbi.nlm.nih.gov/36461911/
    • Cvrljevic AN, Butt U, Huhtinen K, Grönroos TJ, Böckelman C, Lassus H, Butzow R, Haglund C, Kaipio K, Arsiola T, Laajala TD, Connolly DC, Ristimäki A, Carpen O, Pouwels J, Westermarck J. Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype. Mol Cancer Ther. 2022 Jul 5;21(7):1236-1245. doi: 10.1158/1535-7163.MCT-21-0622. PMID: 35364610 https://pubmed.ncbi.nlm.nih.gov/35364610/
    • Denisova OV, Merisaari J, Kaur A, Yetukuri L, Jumppanen M, von Schantz-Fant C, Ohlmeyer M, Wennerberg K, Aittokallio T, Taipale M, Westermarck J. Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells. Sci Rep. 2022 Aug 13;12(1):13796. doi: 10.1038/s41598-022-18118-7. PMID: 35963891 https://pubmed.ncbi.nlm.nih.gov/35963891/
    • Stenvall CA, Nyström JH, Butler-Hallissey C, Jansson T, Heikkilä TRH, Adam SA, Foisner R, Goldman RD, Ridge KM, Toivola DM. Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. Mol Biol Cell. 2022 Nov 1;33(13):ar121. doi: 10.1091/mbc.E20-06-0387. Epub 2022 Aug 24. PMID: 36001365 https://pubmed.ncbi.nlm.nih.gov/36001365

    2021.

    • Laine A, Nagelli SG, Farrington C, Butt U, Cvrljevic AN, Vainonen JP, Feringa FM, Grönroos TJ, Gautam P, Khan S, Sihto H, Qiao X, Pavic K, Connolly DC, Kronqvist P, Elo LL, Maurer J, Wennerberg K, Medema RH, Joensuu H, Peuhu E, de Visser K, Narla G, Westermarck J. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021 Aug 15;81(16):4319-4331. doi: 10.1158/0008-5472.CAN-20-3651. Epub 2021 Jun 18. PMID: 34145035 https://pubmed.ncbi.nlm.nih.gov/34145035/
    • Al-Akhrass H, Conway JRW, Poulsen ASA, Paatero I, Kaivola J, Padzik A, Andersen OM, Ivaska J. A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene. 2021 Feb;40(7):1300-1317. doi: 10.1038/s41388-020-01604-5. Epub 2021 Jan 8. PMID: 33420373 https://pubmed.ncbi.nlm.nih.gov/33420373/

    2020.

    • Khan MM, Välikangas T, Khan MH, Moulder R, Ullah U, Bhosale SD, Komsi E, Butt U, Qiao X, Westermarck J, Elo LL, Lahesmaa R. Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells. Curr Res Immunol. 2020 Dec;1:10-22. doi: 10.1016/j.crimmu.2020.02.001. PMID: 33817627 https://pubmed.ncbi.nlm.nih.gov/33817627/
    • Kauko O, Imanishi SY, Kulesskiy E, Yetukuri L, Laajala TD, Sharma M, Pavic K, Aakula A, Rupp C, Jumppanen M, Haapaniemi P, Ruan L, Yadav B, Suni V, Varila T, Corthals GL, Reimand J, Wennerberg K, Aittokallio T, Westermarck J. Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.  J Biol Chem. 2020 Mar 27;295(13):4194-4211. doi: 10.1074/jbc.RA119.011265. Epub 2020 Feb 18. PMID: 32071079 https://pubmed.ncbi.nlm.nih.gov/32071079/

    2019.

    • Chakroborty D, Kurppa KJ, Paatero I, Ojala VK, Koivu M, Tamirat MZ, Koivunen JP, Jänne PA, Johnson MS, Elo LL, Elenius K. An unbiased in vitro screen for activating epidermal growth factor receptor mutations. J Biol Chem. 2019 Jun 14;294(24):9377-9389. doi: 10.1074/jbc.RA118.006336. Epub 2019 Apr 5. PMID: 30952700 https://pubmed.ncbi.nlm.nih.gov/30952700/
    • Mäkelä E, Löyttyniemi E, Salmenniemi U, Kauko O, Varila T, Kairisto V, Itälä-Remes M, Westermarck J. Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia. Cancers (Basel). 2019 Nov 11;11(11):1774. doi: 10.3390/cancers11111774. PMID: 31717978 https://pubmed.ncbi.nlm.nih.gov/31717978/
    • Pietilä M, Sahgal P, Peuhu E, Jäntti NZ, Paatero I, Närvä E, Al-Akhrass H, Lilja J, Georgiadou M, Andersen OM, Padzik A, Sihto H, Joensuu H, Blomqvist M, Saarinen I, Boström PJ, Taimen P, Ivaska J. SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nat Commun. 2019 May 28;10(1):2340. doi: 10.1038/s41467-019-10275-0. PMID: 31138794 https://pubmed.ncbi.nlm.nih.gov/31138794/

    2018.

    • Mohammad H, Marchisella F, Ortega-Martinez S, Hollos P, Eerola K, Komulainen E, Kulesskaya N, Freemantle E, Fagerholm V, Savontaus E, Rauvala H, Peterson BD, van Praag H, Coffey ET. JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche. Mol Psychiatry. 2018 Feb;23(2):362-374. doi: 10.1038/mp.2016.203. Epub 2016 Nov 15. PMID: 27843149 https://pubmed.ncbi.nlm.nih.gov/27843149/
    • Joly AL, Seitz C, Liu S, Kuznetsov NV, Gertow K, Westerberg L, Paulsson-Berne G, Hansson GK, Andersson J. Alternative splicing of FOXP3 controls regulatory T cell effector functions and is associated with human atherosclerotic plaque stability. Circ Res. 2018 May 11;122(10):1385-1394. doi: 10.1161/CIRCRESAHA.117.312340. Epub 2018 Apr 4. PMID: 29618596  https://pubmed.ncbi.nlm.nih.gov/29618596/
    • Kur-Piotrowska A, Bukowska J, Kopcewicz MM, Dietrich M, Nynca J, Slowinska M, Gawronska-Kozak B. Foxn1 expression in keratinocytes is stimulated by hypoxia: further evidence of its role in skin wound healing. Sci Rep. 2018 Apr 3;8(1):5425. doi: 10.1038/s41598-018-23794-5. PMID: 29615703 https://pubmed.ncbi.nlm.nih.gov/29615703/

    2017.

    • Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Rivero-Muller A, Padzik A, Anisimowicz S, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA. Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice. Cell Physiol Biochem. 2017;43(3):1064-1076. doi: 10.1159/000481718. Epub 2017 Oct 4. PMID: 28977799  https://pubmed.ncbi.nlm.nih.gov/28977799/
    • Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J . FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045. Epub 2017 Aug 1. PMID: 28765364 https://pubmed.ncbi.nlm.nih.gov/28765364/
    • Jurado Acosta A, Rysä J, Szabo Z, Moilanen AM, Komati H, Nemer M, Ruskoaho H. Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression. Cell Tissue Res. 2017 Feb;367(2):369-385. doi: 10.1007/s00441-016-2527-2. Epub 2016 Nov 8. PMID: 27826738 https://pubmed.ncbi.nlm.nih.gov/27826738/