CIC Featured Image

    Image by: Arafat Siddiqui and Jouko Sandholm

    Image: HGSOC cell nucleus stained with antibodies against DNA damage response (DDR) proteins.

    Background: Cancer development induces changes in cellular DNA damage response (DDR). DNA-targeting chemotherapy aims to wipe out these transformed cells. The intention of this subproject is to visualize DDR protein expression in HGSOC subtypes with different DDR capabilities (e.g. HR-proficient vs. HR-deficient) using various chemotherapeutic treatment combinations. In the confocal microscopy image below, expression of 53BP1 (cyan) and DNA-PKc (magenta) is shown after DNA-intercalating mitoxantrone (a topoisomerase II inhibitor) treatment.

    This image has an empty alt attribute; its file name is Sandholm_Siddiqui-1024x1024.jpg

    Technical information: Image was captured with the Zeiss LSM880 confocal microscope using the Airyscan module and a 63x/1.4 objective.

    The image may not be redistributed without consent from the copyright holder.