CIC Featured Image
Image by: Arafat Siddiqui and Jouko Sandholm
Image: HGSOC cell nucleus stained with antibodies against DNA damage response (DDR) proteins.
Background: Cancer development induces changes in cellular DNA damage response (DDR). DNA-targeting chemotherapy aims to wipe out these transformed cells. The intention of this subproject is to visualize DDR protein expression in HGSOC subtypes with different DDR capabilities (e.g. HR-proficient vs. HR-deficient) using various chemotherapeutic treatment combinations. In the confocal microscopy image below, expression of 53BP1 (cyan) and DNA-PKc (magenta) is shown after DNA-intercalating mitoxantrone (a topoisomerase II inhibitor) treatment.
![This image has an empty alt attribute; its file name is Sandholm_Siddiqui-1024x1024.jpg](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_1024,h_1024/https://bioscience.fi/wp-content/uploads/2024/04/image.jpeg)
Technical information: Image was captured with the Zeiss LSM880 confocal microscope using the Airyscan module and a 63x/1.4 objective.
The image may not be redistributed without consent from the copyright holder.