Master’s theses

Karmacharya, Pragya. Characterization of the dynamics of novel conjugated bile acids in relation to the development of islet cell autoantibodies. 2023. link

Scientific articles

Thapa K, Kadiri JJ, Saukkonen K, Pennanen I, Ghimire B, Cai M, Savontaus E, Rinne P. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver. Elife. 2023 Jul 25;12:e84782. doi: 10.7554/eLife.84782. PMID: 37490042; PMCID: PMC10368426.link

Lamichhane S, Sen P, Dickens AM, Kråkström M, Ilonen J, Lempainen J, Hyöty H, Lahesmaa R, Veijola R, Toppari J, Hyötyläinen T, Knip M, Orešič M. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023 Sep 6;14:1211015. doi: 10.3389/fendo.2023.1211015. PMID: 37745723; PMCID: PMC10516565.link

Kråkström M, Dickens AM, Alves MA, Forssten SD, Ouwehand AC, Hyötyläinen T, Orešič M, Lamichhane S. Dynamics of the Lipidome in a Colon Simulator. Metabolites. 2023 Feb 27;13(3):355. doi: 10.3390/metabo13030355. PMID: 36984795; PMCID: PMC10051596.link

Chester LA, Englund A, Chesney E, Oliver D, Wilson J, Sovi S, Dickens AM, Oresic M, Linderman T, Hodsoll J, Minichino A, Strang J, Murray RM, Freeman TP, McGuire P. Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study. Cannabis Cannabinoid Res. 2022 Dec 9. doi: 10.1089/can.2022.0174. Epub ahead of print. PMID: 36493386.link

Kantonen T, Pekkarinen L, Karjalainen T, Bucci M, Kalliokoski K, Haaparanta-Solin M, Aarnio R, Dickens AM, von Eyken A, Laitinen K, Houttu N, Kirjavainen AK, Helin S, Hirvonen J, Rönnemaa T, Nuutila P, Nummenmaa L. Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB1 receptor availability. Int J Obes (Lond). 2022 Feb;46(2):400-407. doi: 10.1038/s41366-021-00996-y. Epub 2021 Nov 2. PMID: 34728775; PMCID: PMC8794779.link

Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, Kråkström M, Retel Helmrich IRA, Wang KKW, Maas AIR, Steyerberg EW, Menon DK, Tenovuo O, Hyötyläinen T, Büki A, Orešič M; CENTER-TBI Participants and Investigators. Serum metabolome associated with severity of acute traumatic brain injury. Nat Commun. 2022 May 10;13(1):2545. doi: 10.1038/s41467-022-30227-5. PMID: 35538079; PMCID: PMC9090763.link

Lamichhane S, Sen P, Dickens AM, Alves MA, Härkönen T, Honkanen J, Vatanen T, Xavier RJ, Hyötyläinen T, Knip M, Orešič M. Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Cell Rep Med. 2022 Oct 18;3(10):100762. doi: 10.1016/j.xcrm.2022.100762. Epub 2022 Oct 3. PMID: 36195095; PMCID: PMC9589006.link

Lamichhane S, Dickens AM, Sen P, Laurikainen H, Borgan F, Suvisaari J, Hyötyläinen T, Howes O, Hietala J, Orešič M. Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis. Schizophr Bull. 2021 Jan 23;47(1):160-169. doi: 10.1093/schbul/sbaa087. PMID: 32609372; PMCID: PMC7825089.link

Dickens AM, Sen P, Kempton MJ, Barrantes-Vidal N, Iyegbe C, Nordentoft M, Pollak T, Riecher-Rössler A, Ruhrmann S, Sachs G, Bressan R, Krebs MO, Amminger GP, de Haan L, van der Gaag M, Valmaggia L, Hyötyläinen T; EU-GEI High Risk Study Group; Orešič M, McGuire P. Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biol Psychiatry. 2021 Feb 1;89(3):288-297. doi: 10.1016/j.biopsych.2020.07.012. Epub 2020 Jul 25. PMID: 32928501.link

Sen P, Andrabi SBA, Buchacher T, Khan MM, Kalim UU, Lindeman TM, Alves MA, Hinkkanen V, Kemppainen E, Dickens AM, Rasool O, Hyötyläinen T, Lahesmaa R, Orešič M. Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways. Cell Rep. 2021 Nov 9;37(6):109973. doi: 10.1016/j.celrep.2021.109973. PMID: 34758307.link