Publications

ECCB2024: The 23rd European Conference on Computational Biology

Anu Kukkonen-Macchi et al.

Bioinformatics. 2024 Sep 1;40(Suppl 2):ii1-ii3. doi: 10.1093/bioinformatics/btae422.

No abstract

Intermediate filaments at a glance

Leila S Coelho-Rato et al.

J Cell Sci. 2024 Aug 15;137(16):jcs261386. doi: 10.1242/jcs.261386. Epub 2024 Aug 29.

Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural support to cells, as well as active roles in mechanical support and signaling pathways. Consequently, defects in IFs are associated with more than 100 diseases. In this Cell Science at a Glance article, we discuss the established classes of IFs and their general...

Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis

Xiwen Geng et al.

Smart Med. 2024 May 22;3(2):e20240004. doi: 10.1002/SMMD.20240004. eCollection 2024 Jun.

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we have developed antibacterial iron-doped nanozymes (Fe^(3+)-doped nanozymes, FNEs) with distinguished capacity to fight against bacterial infections. The iron-doped nanozymes are composed of Fe^(3+) doped zeolitic imidazolate framework-8 (Fe/ZIF-8) and polyethylene imide (PEI), which were functionally...

Emerging ctDNA detection strategies in clinical cancer theranostics

Kexin Yi et al.

Smart Med. 2023 Nov 13;2(4):e20230031. doi: 10.1002/SMMD.20230031. eCollection 2023 Nov.

Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor-specific gene mutations and other valuable information. ctDNA is considered to be one of the most significant analytes in liquid biopsies. Over the past decades, numerous researchers have developed various detection strategies to perform quantitative or qualitative ctDNA analysis, including PCR-based detection and sequencing-based detection. More and more...

Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors

Ahmed Sabt et al.

PLoS One. 2024 Aug 14;19(8):e0306124. doi: 10.1371/journal.pone.0306124. eCollection 2024.

Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR. Nine compounds consisting of coumarin-6-sulfonamide linked to chalcone derivatives were synthesized and evaluated for their ability to inhibit hGSTP1-1. Among the synthetic derivatives, compounds 5g, 5f, and 5a displayed the most potent inhibitory effect, with...

CellTracksColab is a platform that enables compilation, analysis, and exploration of cell tracking data

Estibaliz Gómez-de-Mariscal et al.

PLoS Biol. 2024 Aug 8;22(8):e3002740. doi: 10.1371/journal.pbio.3002740. eCollection 2024 Aug.

In life sciences, tracking objects from movies enables researchers to quantify the behavior of single particles, organelles, bacteria, cells, and even whole animals. While numerous tools now allow automated tracking from video, a significant challenge persists in compiling, analyzing, and exploring the large datasets generated by these approaches. Here, we introduce CellTracksColab, a platform tailored to simplify the exploration and analysis of cell tracking data. CellTracksColab facilitates...