Social stress is a risk factor for psychiatric disorders and also influences immune function. While it is known that acute social stress impacts the number... Read more

Multiple sclerosis (MS) is an autoimmune disease characterized by immune cell dysregulation. HLA class II alleles drive the disease risk, thereby highlighting CD4^(+) T cells... Read more

Nitric oxide (NO)-based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a... Read more

Understanding host-pathogen interactions during Mycobacterium tuberculosis (Mtb) infection has largely relied on identifying bacterial genes essential for intracellular survival. However, conventional reverse genetics approaches often... Read more

INTRODUCTION: Traumatic brain injury (TBI) is a major cause of long-term disability worldwide, but the pathophysiological mechanisms underlying its chronic sequelae remain incompletely understood. In... Read more

Maternal exposure to persistent organic pollutants (POPs) has been linked with adverse pregnancy and birth outcomes, yet the underlying biological pathways involved remain poorly characterized.... Read more

Zebrafish models are widely used to study BRAF-mutant melanoma biology. However, long-term treatment of adult fish with small molecule BRAF inhibitors remains challenging, and pharmacokinetic... Read more

The immune system has emerged as a critical factor influencing neurodevelopment in offspring. While this is increasingly well-studied in the context of maternal immune activation... Read more

Colorectal cancer (CRC) patients with microsatellite-stable tumors typically resist immune checkpoint blockade (ICB) due to an immunosuppressive "cold" microenvironment. Photodynamic therapy (PDT) generates reactive oxygen... Read more

Stress-generating therapeutic materials are commonly optimized to deliver cytotoxic inputs, but delivery alone does not determine whether intracellular stress becomes irreversible damage. Tumor cells can... Read more

Multi-omics approaches have revolutionized our understanding of microbial communities by enabling simultaneous interrogation of genomic, transcriptomic, proteomic, and metabolomic data. The systematic integration and analysis... Read more

CONCLUSIONS: Higher measured physical activity was inversely associated with detection of csPCa in men with suspicion of PCa. Active smoking also showed an inverse association.... Read more