Symposium pre-seminars: Jim Norman and Fiona Watt

    In addition to the student mini-symposium, there are two events linked to the upcoming BioCity Symposium.

    EVENT 1 – CellCom-sponsored seminar by Professor Jim Norman (CRUK Beatson Institute, Glasgow, UK).

    • Details: Professor Norman will speak to us about “exploiting the circulating metabolome to discover critical events in cancer invasion and metastasis”. Professor Norman is attending the BioCity symposium, so you can catch him there on Thursday and Friday.
    • When: August, Wednesday 23rd, 11 a.m. – 12 p.m. Coffee and pulla for the first 35 people (please arrive a few minutes earlier)!
    • Where: Biocity building, Åbo Akademi, 3rd floor Biochemistry seminar room, A-side (lab side, visible from the 3rd floor lobby)


    EVENT 2 – EMBO matters by Professor Fiona Watt (EMBO director)

    • Details: Next year marks the 60th anniversary of the European Molecular Biology Organization (EMBO). EMBO funds researchers as well as conferences, training and networking activities to help create an environment in which scientists can excel. Now will be a time to celebrate, to reflect on past achievements and challenges, and also to look ahead to the future of the life sciences and the role EMBO will play in it. Professor Watt will open this unique meeting and then we will hear the perspectives of EMBO postdocs and members. This meeting is open to all wanting to connect to the EMBO community. Professor Watt is also attending the symposium, where she will talk about “exploring stem cell dynamics in human skin”.
    • When: August, Wednesday 23rd, 1:30 – 4pm (with coffee and biscuits, please arrive a few minutes earlier)!
    • Tentative program:
      • 1.30pm – 2pm Fiona Watt: presentation on EMBO programmes
      • 2-2.15pm Q+A
      • 2.15pm – 2.30pm Yilin Kang: perspectives of an EMBO postdoc
      • 2.30 – 2.45pm Mathilde Mathieu: perspectives of an EMBO postdoc
      • 2.45 – 3pm Q+A
      • 3 – 3.30pm Johanna Ivaska: perspectives of an EMBO member
      • 3.30 – 4pm Q+A and summary of the event
    • Where: Biocity building, Åbo Akademi, 3rd floor Biochemistry seminar room, A-side (lab side, visible from the 3rd floor lobby)



    Selected recent publications of Jim Norman

    • Wilson B, Flett C, Gemperle J, Lawless C, Hartshorn M, Hinde E, Harrison T, Chastney M, Taylor S, Allen J, Norman JC, Zacharchenko T, Caswell PT. Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families. J Cell Sci. 2023 Jun 15;136(12):jcs260468. doi: 10.1242/jcs.260468. Epub 2023 Jun 23. PMID: 37232246; PMCID: PMC10323252.
    • Marco S, Neilson M, Moore M, Perez-Garcia A, Hall H, Mitchell L, Lilla S, Blanco GR, Hedley A, Zanivan S, Norman JC. Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nat Commun. 2021 Nov 24;12(1):6829. doi: 10.1038/s41467-021-26839-y. PMID: 34819513; PMCID: PMC8613289.
    • Rabas N, Palmer S, Mitchell L, Ismail S, Gohlke A, Riley JS, Tait SWG, Gammage P, Soares LL, Macpherson IR, Norman JC. PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. J Cell Biol. 2021 Dec 6;220(12):e202006049. doi: 10.1083/jcb.202006049. Epub 2021 Oct 8. PMID: 34623384; PMCID: PMC8641410.
    • Koessinger AL, Koessinger D, Stevenson K, Cloix C, Mitchell L, Nixon C, Gomez-Roman N, Chalmers AJ, Norman JC, Tait SWG. Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Sci Rep. 2020 Sep 21;10(1):15361. doi: 10.1038/s41598-020-72322-x. PMID: 32958777; PMCID: PMC7506024.
    • Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC. Mutant p53s generate pro- invasive niches by influencing exosome podocalyxin levels. Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y. PMID: 30498210; PMCID: PMC6265295.
    • Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, Mackay G, Sumpton D, Pallares M, Nixon C, Blyth K, Macpherson IR, Rainero E, Norman JC. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nat Commun. 2017 Dec 21;8(1):2255. doi: 10.1038/s41467-017-02101-2. PMID: 29269878; PMCID: PMC5740148.
    • Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell PT, Campbell AD, Hogeweg A, Sansom OJ, Morton JP, Norman JC. Phosphorylation of Rab- coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nat Commun. 2017 Mar 15;8:14646. doi: 10.1038/ncomms14646. PMID: 28294115; PMCID: PMC5355957.
    • Diaz-Vera J, Palmer S, Hernandez-Fernaud JR, Dornier E, Mitchell LE, Macpherson I, Edwards J, Zanivan S, Norman JC. A proteomic approach to identify endosomal cargoes controlling cancer invasiveness. J Cell Sci. 2017 Feb 15;130(4):697-711. doi: 10.1242/jcs.190835. Epub 2017 Jan 6. PMID: 28062852; PMCID: PMC5339883.
    • Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC. The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis. Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3. PMID: 26948875; PMCID: PMC4819511.

    Macpherson IR, Rainero E, Mitchell LE, van den Berghe PV, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P, Norman JC. CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. J Cell Sci. 2014 Sep 15;127(Pt 18):3893-901. doi: 10.1242/jcs.135947. Epub 2014 Jul 11. PMID: 25015290.