Publications

    PUBLICATION

    PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments 

    Mario Del Rosario et al.

    Nat Commun. 2025 Dec 13. doi: 10.1038/s41467-025-66209-6. Online ahead of print.

    Published on December 13, 2025

    Phototoxicity in live-cell fluorescence microscopy can compromise experimental outcomes, yet quantitative methods to assess its impact remain limited. Here, we present PhotoFiTT (Phototoxicity Fitness Time Read more

    PUBLICATION

    A resource to empirically establish drug exposure records directly from untargeted metabolomics data 

    Haoqi Nina Zhao et al.

    Nat Commun. 2025 Dec 9;16(1):10600. doi: 10.1038/s41467-025-65993-5.

    Published on December 9, 2025

    Despite extensive efforts, extracting medication exposure information from clinical records remains challenging. To complement this approach, here we show the Global Natural Product Social Molecular Read more

    PUBLICATION

    Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity 

    Santosh Lamichhane et al.

    Nat Commun. 2025 Dec 3. doi: 10.1038/s41467-025-66619-6. Online ahead of print.

    Published on December 3, 2025

    Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health Read more

    PUBLICATION

    Mitochondria-Targeted Nanomotor: H2S-Driven Cascade Therapy for Hepatocellular Carcinoma 

    Chengcheng Li et al.

    Adv Mater. 2025 Dec 1:e13757. doi: 10.1002/adma.202513757. Online ahead of print.

    Published on December 2, 2025

    Despite advances in combination therapies for cancer treatment, most strategies rely on modular-additive designs that lack dynamic molecular cues to achieve intrinsic synergy. Herein, a Read more

    PUBLICATION

    Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway 

    Martina Lerche et al.

    J Cell Biol. 2026 Feb 2;225(2):e202508155. doi: 10.1083/jcb.202508155. Epub 2025 Dec 2.

    Published on December 2, 2025

    Constitutive integrin endocytosis and recycling control cell movement and morphology. In contrast, the role of newly synthesized integrins delivered via the biosynthetic pathway has been Read more

    PUBLICATION

    JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation 

    Ye Hong et al.

    Neurobiol Dis. 2025 Nov 29;218:107207. doi: 10.1016/j.nbd.2025.107207. Online ahead of print.

    Published on November 30, 2025

    c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo Read more

    PUBLICATION

    Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation 

    Yu Zhang et al.

    Adv Mater. 2025 Nov 28:e18378. doi: 10.1002/adma.202518378. Online ahead of print.

    Published on November 28, 2025

    The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune Read more

    PUBLICATION

    Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism 

    Sepideh Parvanian et al.

    Eur J Cell Biol. 2025 Nov 21;104(4):151523. doi: 10.1016/j.ejcb.2025.151523. Online ahead of print.

    Published on November 27, 2025

    Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of Read more

    PUBLICATION

    Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase 

    Charoutioun S Bodourian et al.

    Protein Sci. 2025 Dec;34(12):e70396. doi: 10.1002/pro.70396.

    Published on November 26, 2025

    The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting Read more

    PUBLICATION

    Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles 

    Shrikant B Kokate et al.

    Curr Biol. 2025 Nov 25:S0960-9822(25)01462-9. doi: 10.1016/j.cub.2025.10.081. Online ahead of print.

    Published on November 26, 2025

    Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their Read more

    PUBLICATION

    Dynamics of gut metabolome and microbiota maturation during early life 

    Anna-Katariina Aatsinki et al.

    iScience. 2025 Sep 25;28(11):113596. doi: 10.1016/j.isci.2025.113596. eCollection 2025 Nov 21.

    Published on November 24, 2025

    Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This Read more

    PUBLICATION

    Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation 

    Thinh Thi Kim Truong et al.

    J Oral Biosci. 2025 Dec;67(4):100691. doi: 10.1016/j.job.2025.100691. Epub 2025 Aug 19.

    Published on November 22, 2025

    CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression Read more