Publications

    PUBLICATION

    Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice 

    iScience. 2024 Jan 15;27(2):108914. doi: 10.1016/j.isci.2024.108914. eCollection 2024 Feb 16.

    Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during early mouse embryogenesis and that embigin is essential for lung development. Markedly increased neonatal mortality of Emb-/- mice can be explained by the compromised lung maturation: in Emb-/- mice (E17.5) the number and the size of the small airways and distal airspace are significantly smaller, there are fewer ATI and ATII cells, and the alkaline phosphatase activity in amniotic fluid is lower. Emb-/- lungs show less peripheral branching already at E12.5, and embigin is highly expressed in lung primordium. Thus, embigin function is essential at early pseudoglandular stage or even earlier. Furthermore, our RNA-seq analysis and Ki67 staining results support the idea that the development of Emb-/- lungs is rather delayed than defected.

    Published on December 10, 2024

    Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone Read more

    PUBLICATION

    Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss 

    Rawand A Mustaf et al.

    Adv Sci (Weinh). 2024 Nov 21:e2407067. doi: 10.1002/advs.202407067. Online ahead of print.

    Published on November 22, 2024

    Local intratympanic drug delivery to the inner ear possesses significant otological clinical promise as cisplatin-induced hearing loss (CIHL) therapy, inducing significantly less side effects than Read more

    PUBLICATION

    Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis 

    Silvia Sabatini et al.

    Cell Rep Med. 2024 Nov 19;5(11):101820. doi: 10.1016/j.xcrm.2024.101820.

    Published on November 20, 2024

    Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with a high prevalence of type 2 diabetes (T2D). Individuals with MASLD exhibit insulin Read more

    PUBLICATION

    Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids 

    Toni Laine et al.

    Chembiochem. 2025 Mar 15;26(6):e202400908. doi: 10.1002/cbic.202400908. Epub 2024 Nov 28.

    Published on November 15, 2024

    Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide Read more

    PUBLICATION

    Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients 

    Annamaria Petrilla et al.

    Sci Rep. 2024 Nov 8;14(1):27179. doi: 10.1038/s41598-024-78102-1.

    Published on November 8, 2024

    Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx Read more

    PUBLICATION

    The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF 

    Joshua Klein et al.

    Anal Chem. 2024 Nov 19;96(46):18491-18501. doi: 10.1021/acs.analchem.4c04091. Epub 2024 Nov 8.

    Published on November 8, 2024

    Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream Read more

    PUBLICATION

    Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C: A Six Patient Case Series 

    Sara Gracie et al.

    Am J Med Genet A. 2025 Mar;197(3):e63927. doi: 10.1002/ajmg.a.63927. Epub 2024 Nov 6.

    Published on November 6, 2024

    Heterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by infantile-onset epilepsy, frontal cortical Read more

    PUBLICATION

    Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors 

    Abraham Kuri Cruz et al.

    Metabolomics. 2024 Nov 4;20(6):125. doi: 10.1007/s11306-024-02185-0.

    Published on November 4, 2024

    CONCLUSION: This collaborative exercise emphasized the broad chemical survey possible with multi-technique approaches. Community engagement is essential for the evaluation and characterization of common materials Read more

    PUBLICATION

    xCT as a Predictor for Survival in a Population-Based Cohort of Head and Neck Squamous Cell Carcinoma 

    Linda Nissi et al.

    Cancer Med. 2024 Nov;13(21):e70371. doi: 10.1002/cam4.70371.

    Published on November 2, 2024

    CONCLUSIONS: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value Read more

    PUBLICATION

    Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy 

    Afonso Mendes et al.

    Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5182329. doi: 10.21203/rs.3.rs-5182329/v1.

    Published on November 1, 2024

    From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can Read more

    PUBLICATION

    Imaging cell architecture and dynamics 

    Lucy Collinson et al.

    J Cell Sci. 2024 Oct 15;137(20):jcs263575. doi: 10.1242/jcs.263575. Epub 2024 Oct 30.

    Published on October 30, 2024

    No abstract

    PUBLICATION

    Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer 

    Karolina Punovuori et al.

    Cell. 2024 Dec 12;187(25):7267-7284.e20. doi: 10.1016/j.cell.2024.09.046. Epub 2024 Oct 28.

    Published on October 29, 2024

    Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly Read more