Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy

    Authors: Yonghui Wang, Chang Liu, Xiaodong Ma, Anne Filppula, Youbin Cui, Jiangbin Ye, Hongbo Zhang

    Journal: Nanoscale

    Year: 2024

    DOI: https://doi.org/10.1039/d4nr02471k

    Abstract

    In this study, our innovative Mito@ZiF-8 system enhances the functionality of isolated mitochondria and reprograms M2 macrophage metabolism upon delivery, ultimately, reducing the tumorigenic potential of breast cancer cells.