Event Details

11^th December at 12:00
Onsite event
in Presidentti auditorium, BioCity
Autumn 2025 program

Prof. Marco Demaria, University of Groningen, The Netherlands
Heterogeneity in cellular senescence: from mechanisms to interventions

Host: Gennady Yegutkin (genyeg@utu.fi)

No coffee nor sandwiches this time, but lunch instead!

BioCity Turku wants to thank all its people from the great 2025 which was full of great events and good vibes. After Prof. Demaria’s talk there is lunch served in BioCity 1^st floor lobby. There are seats for 150 first ones to register and we hope many of you can make it.

Register here: https://link.webropolsurveys.com/S/A24F2F06197BBA30

Dr Demaria is an associate professor in Cellular Ageing and his research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. His laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs.

Selected publications

Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer. Nehme J, Maassen S, Bravaccini S, Zanoni M, Gianni C, De Giorgi U, Soto-Gamez A, Altulea A, Gheorghe T, Wang B, Demaria M. EMBO J. 2025 Feb 10

Guidelines for minimal information on cellular senescence experimentation in vivo. Ogrodnik M, Carlos Acosta J, Adams PD, d’Adda di Fagagna F, …, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M. Cell. 2024 Aug 8;187(16):4150-4175

Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury. Nehme J, Mesilmany L, Varela-Eirin M, Brandenburg S, Altulea A, Lin Y, Gaya da Costa M, Seelen M, Hillebrands JL, van Goor H, Saab R, Akl H, Prevarskaya N, Farfariello V, Demaria M.Nat Aging. 2024 Jun;4(6):771-782

The Quest to Define and Target Cellular Senescence in Cancer. Wang B, Demaria M. Cancer Res. 2021 Dec 15;81(24):6087-6089.

General information

• You can download and save all the autumn 2025 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2025 image credits to Kari Kaunisto: Sahlberg family collections, Biodiversity unit, University of Turku