Updates

Immunology Seminar

December 7 at 14-15
Virtual event

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Tuure Kinnunen, University of Eastern Finland: T cell studies in type 1 diabetes

Host: Riitta Lahesmaa (rilahes@utu.fi)

Register latest December 5th at: https://link.webropolsurveys.com/S/111057C69B07821C

Zoom link and iCalendar invitation to join the online event will be sent to all registered participants one day before the event.

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi), University of Turku.

Dr. Tuure Kinnunen is currently Professor of Clinical Microbiology and Immunology at the University of Eastern Finland. He finished his MD in 2005 and his PhD in immunology in 2007 at the University of Kuopio. Between 2010-2011 he worked as post-doctoral fellow at Yale University, USA. After returning to Finland, he finished his clinical training in Clinical Microbiology in 2012.

The research of Dr. Kinnunen has focused on translational human immunology, in particular examining the mechanisms of allergy, autoimmune diseases and primary immune deficiencies. Since starting his own research group in 2012, the main research focus of the group has been immunology of type 1 diabetes. In collaboration with the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study the group has completed multiple studies analyzing alterations in blood immune cell populations during the progression to clinical type 1 diabetes.

Selected publications:

1)         Gazali AM, Schroderus AM, Näntö-Salonen K, Rintamäki R, Pihlajamäki J, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T. Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes. Diabetologia 2020 Nov;63(11):2396-2409.

2)         Valta M, Gazali AM, Viisanen T, Ihantola EL, Ekman I, Toppari J, Knip M, Veijola R, Ilonen J, Lempainen J, Kinnunen T. Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells. Eur J Immunol. 2020 Apr;50(4):581-588.

3)         Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T. Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes. Diabetologia. 2019 Sep;62(9):1681-1688.

4)         Viisanen T, Gazali AM, Ihantola E-L, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J and Kinnunen T. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children. Front Immunol. 2019 Jan 22;10:19.

5)         Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children with Multiple Autoantibodies. Diabetes. 2017 Feb;66(2):437-447.